The Stefanie Spielman Fund for Breast Cancer Research is devoted to advancing research in breast cancer.
One of the OSUCCC – James researchers who is carrying Stefanie’s dream of a cancer-free world through their work is Erin Olson, MD in the Division of Medical Oncology. She is running a research study funded entirely by the Spielman Fund called, “MEK and AKT Inhibition in Patients With Advanced Triple Negative Breast Cancer”. Because patients with triple negative breast cancer (TNBC) have poor clinical outcomes, scientists are seeking new targeted therapies. This study will evaluate the ability of MEK and AKT protein inhibitor-based therapies to cause a durable antitumor response in advanced TNBC and to understand predictors of sensitivity and mechanisms of resistance to these agents. This approach will involve the first clinical trial to evaluate a novel targeted combination strategy for metastatic TNBC.
Over the past few years, the fund has also supported researchers and their efforts. Currently, the fund is focused on supporting the following areas:
- The Stefanie Spielman Chair in Cancer Imaging. Michael Tweedle, PhD, serves in this chair. His work focuses on targeted molecular pharmaceuticals for imaging and therapy of cancer.
- Researchers in the Ohio State University School of Pharmacy and the Comprehensive Cancer Center are developing new drugs for breast cancer. The fund will support continued efforts to discover and test these new drugs in clinical trials.
- An invaluable resource to support breast cancer research is a large collection of breast cancers characterized by all the relevant pathological features of the cancers and the treatments and outcomes of the patients with these breast cancers. The fund is supporting two such efforts, the Spielman Breast Cancer Tissue Archive Services and Spielman Breast Cancer Tumor Bank. The Tissue Archive Services, under the leadership of Charles Shapiro MD, Director of Breast Cancer Medical Oncology at Ohio State, uses breast cancers already collected and stored in the Ohio State pathology department. The Tumor Bank collects breast cancers and blood samples from newly diagnosed patients. The Tissue Archive Services and the Tumor Bank allows for promising genes or proteins that first are discovered in the laboratory using cell lines or animal models to be quickly tested for their importance and relevance to human breast cancers that come from patients. Examples of ongoing research conducted using these resources include: the molecular factors associated with basaloid, or estrogen receptor negative, progesterone receptor negative and HER-2 negative (or “triple negative”) breast cancers, and the molecular factors associated with tamoxifen resistance.
Make a gift to the Stefanie Spielman Fund for Breast Cancer Research online.
The Stefanie Spielman Fund for Patient Assistance assists breast cancer patients and their families who are struggling to afford the costs associated with treatment. The fund has provided essential equipment and services, including circulation pumps for lymphedema, compression garments, wigs, nutrition supplements, gas cards, restaurant gift cards and assistance with transportation.
Make a gift to the Stefanie Spielman Fund for Patient Assistance online.