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Thoracic Clinical Trials

With an emphasis on transdisciplinary translational research, the OSUCCC-James facilitates investigator-initiated early phase clinical trials and participates in many cooperative groups.

Protocol No.PITitle
OSU-10112Erin BertinoEnhancement of Cetuximab-induced antibody-dependent cellular cytotoxicity (ADCC) with Lenalidomide in Advanced Solid Tumors: A Phase I/IB study
OSU-12117Erin BertinoA Study of HSP90 Inhibitor AT13387 Alone and in Combination with Crizotinib in the Treatment of Non-small Cell Lung Cancer (NSCLC)
OSU-12012Kristy BrowningDeveloping an ePersonal Health Record (PHR) for delivery of tobacco dependence treatment to oncology patients who smoke
RTOG-0813Virginia DiavolitsisSeamless Phase I/II Study of Stereotactic Lung Radiotherapy (SBRT) for Early Stage, Centrally Located, Non-Small Cell Lung Cancer (NSCLC) in Medically Inoperable Patients.
CALGB-30610John GreculaPhase III Comparison of Thoracic Radiotherapy Regimens in Patients with Limited Small Cell Lung Cancer also Receiving Cisplatin and Etoposide
OSU-08111John GreculaMR-Predictive-Assay in Pre-Operative Lung Cancer Therapy: Response/Resectability
CALGB-150712John GreculaEmbedded Companion Study to CALGB 30610
CALGB-70702John GreculaEmbedded Companion to CALGB 30610
OSU-09027Edward KimUse of PET-CT in Neoadjuvant Chemoradiation Therapy for Stage IIIA NSCLC
CALGB-150704Kavitha KosuriEmbedded Companion Study to CALGB-30605
CALGB-70701Kavitha KosuriEmbedded Companion Study to CALGB-30607
CALGB-60702Kavitha KosuriEmbedded Companion Study to CALGB-30607
CALGB-150707Kavitha KosuriEmbedded Substudy "A Phase II Study of Dasatinib (NSC # 732517) in Patient w/ Previously Treated Malignant Mesothelioma"
OSU-11014Joanne LesterIncidence and Characterization of Postoperative Ipsilateral Shoulder Pain in Thoracic Surgical Patients
OSU-07115Susan Moffatt-BruceImmunobiology of Photodynamic Therapy in Lung Cancer Patients
OSU-08113Ryan NiederkohrRetrospective Evaluation of the Prognostic Value of Total Tumor Volume Versus SUV in Patients with Lung Cancer Undergoing FDG PET/CT
CALGB-150701Greg OttersonEmbedded Companion Study to CALGB-30504
CALGB-60705Greg OttersonEmbedded Companion Study to CALGB 30704
CALGB-580702Greg OttersonEmbedded Campanion Study to CALGB 30704
OSU-11144Greg OttersonA RANDOMIZED, PHASE III, MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY EVALUATING THE EFFICACY AND SAFETY OF MetMAb IN COMBINATION WITH TARCEVA (ERLOTINIB) IN PATIENTS WITH MET DIAGNOSTIC−POSITIVE NON−SMALL CELL LUNG CANCER (NSCLC) WHO HAVE RECEIVED STANDARD CHEMOTHERAPY FOR ADVANCED OR METASTATIC DISEASE
OSU-11192Greg OttersonRandomized Phase II Study of Single Agent OSI-906, an Oral, Small Molecule, Tyrosine Kinase Inhibitor (TKI) of the Insulin Growth Factor-1 Receptor (IGF-1R) Versus Topotecan for the Treatment of Patients with Relapsed Small Cell Lung Cancer (SCLC)
OSU-12053Greg OttersonA Randomized Phase II Trial of Erlotinib Alone or In Combination with Bevacizumab in Patients With Non-Small Cell Lung Cancer and Activating Epidermal Growth Factor Receptor Mutations
OSU-12068Greg OttersonLUX-Lung 8: A randomized, open-label Phase III trial of afatinib versus erlotinib in patients with advanced squamous cell carcinoma of the lung as second-line therapy following first-line platinum-based chemotherapy
CALGB-70809Greg OttersonEmbedded Companion to CALGB-30506: Quality of Life in Patients on CALGB-30506
CALGB-30801Greg OttersonA Randomized Phase III Double Blind Trial Evaluating Selective COX-2 Inhibition in COX-2 Expressing Advanced Non-Small Cell Lung Cancer
CALGB-150908Greg OttersonEmbedded Protocol to CALGB-30801
CALGB-60904Greg OttersonEmbedded Companion Studu to CALGB-30801
CALGB-30901Greg OttersonRandomized phase II study of maintenance pemetrexed versus observation for patients with malignant pleural mesothelioma without progression after first-line chemotherapy
CALGB-150912Greg OttersonEmbedded Companion Study to CALGB-30901
CALGB-580903Greg OttersonEmbedded Companion Study to CALGB-30901
ECOG-E5508Greg OttersonRandomized Phase III Study of Maintenance Therapy with Bevacizumab, Pemetrexed, or a Combination of Bevacizumab and Pemetrexed Following Carboplatin, Paclitaxel and Bevacizumab for Advanced Non-Squamous NSCLC
OSU-12183Greg OttersonA Single-Arm Phase 2 Study of BMS-936558 in Subjects with Advanced or Metastatic Squamous Cell Non-Small Cell Lung Cancer Who Have Received At Least Two Prior Systemic Regimens
OSU-12184Greg OttersonLung Cancer Mutation Consortium Protocol
CALGB-151108Greg OttersonCORRELATIVE IMAGING ANALYSIS OF CALGB 30406: ERLOTINIB THERAPY IN LUNG CANCER AS A MODEL FOR THE DEVELOPMENT OF BIOLOGICALLY MEANINGFUL RESPONSE METRICS
OSU-12210Patrick RossRobotic-Assisted Thoracic Surgery (RATS) Patient Registry: PROTOCOL
OSU-12072Patrick RossPhotodynamic Therapy (PDT) Oncology Registry
CALGB-140503Patrick RossA Phase III Randomized Trial of Lobectomy versus Sublobar Resection for Small < 2cm Peripheral Non-Small Cell Lung Cancer
ECOG-1505Patrick RossA Phase III Randomized Trial of Adjuvant Chemotherapy With or Without Bevacizumab for Completely Resected Stage IB-IIIA Non-Small Cell Lung Cancer (NSCLC)
OSU-07082Miguel VillalonaAnalysis of FANCD2 Protein Monoubiquitin Status and Nuclear Foci Formation in the Primary Solid Tumors
OSU-09100Miguel VillalonaABT-888 as monotherapy and in combination with Mitomycin C in patients with solid tumors with deficiency in homologous recombination repair.
OSU-12167Miguel VillalonaA Phase II study of the selective BRAF kinase inhibitor GSK2118436 in subjects with advanced non-small cell lung cancer and BRAF mutations.
RTOG-0937Meng WelliverRANDOMIZED PHASE II STUDY COMPARING PROPHYLACTIC CRANIAL IRRADIATION ALONE TO PROPHYLACTIC CRANIAL IRRADIATION AND CONSOLIDATIVE EXTRA-CRANIAL IRRADIATION FOR EXTENSIVE DISEASE SMALL CELL LUNG CANCER (ED-SCLC)
RTOG-1012Terence WilliamsPhase II Randomized Trial of Prophylactic Manuka Honey for the Reduction of Chemoradiation Therapy Induced Esophagitis-Related Pain During the Treatment of Lung Cancer