Clinical Scientific Review Committee
The Clinical Scientific Review Committee (CSRC) at The Ohio State University Comprehensive Cancer Center (OSUCCC) plays a vital role in protocol review and monitoring to ensure that clinical trials are scientifically sound and that approved trials maintain patient accrual goals and scientific progress.
The CSRC operates in collaboration with the Clinical Trials Office (CTO) while maintaining separate responsibilities and reporting. The CSRC meets twice a month to review all proposed cancer-related protocols conducted at the OSUCCC including the James Cancer Hospital, Columbus Children's Hospital, Cincinnati Children's Hospital and OSU Medical Center. All cancer-related research is required to have prior CSRC approval before the protocol can be submitted to one of the OSU Institutional Review Boards (IRB).
QA audits are performed by the Office for Protocol Compliance. Monitoring for accrual is performed by the CSRC. Serious adverse events (SAEs) are reported by CTO staff to the Cancer IRB, and the routine monitoring of SAEs is performed by the Data Safety and Monitoring Committee.