Samson T. Jacob PhD

Samson T. Jacob PhD
ProfessorCollege of Medicinejacob.42@osu.eduwebsite
646A Tzagournis Med Res Facility 420 W 12th Avenue Columbus Ohio 43210
Phone:614-688-5494Fax: 614-688-5600
  • Experimental Therapeutics
  • Administrative

Current Publications

  • Baiocchi RAGenetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma.Cancer Res 74 1752-65 3/15/2014
  • Hsu SH, Yu B, Wang X, Lu Y, Schmidt CR, Lee RJ, Lee LJ, Jacob ST, Ghoshal KCationic lipid nanoparticles for therapeutic delivery of siRNA and miRNA to murine liver tumor.Nanomedicine 9 1169-80 11/1/2013
  • Wang X, Yu B, Ren W, Mo X, Zhou C, He H, Jia H, Wang L, Jacob ST, Lee RJ, Ghoshal K, Lee LJEnhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations.J Control Release in press 10/8/2013
  • Wang B, Hsu SH, Wang X, Kutay H, Bid HK, Yu J, Ganju R, Jacob S, Yuneva M, Ghoshal KReciprocal regulation of miR-122 and c-Myc in hepatocellular cancer: Role of E2F1 and TFDP2.Hepatology in press 8/28/2013
  • Hsu SH, Motiwala T, Roy S, Claus R, Mustafa M, Plass C, Freitas MA, Ghoshal K, Jacob STMethylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.J Cell Biochem 114(8) 1810-8 8/1/2013
  • Gamage SA, Brooke DG, Redkar S, Datta J, Jacob ST, Denny WAStructure-activity relationships for 4-anilinoquinoline derivatives as inhibitors of the DNA methyltransferase enzyme DNMT1.Bioorg Med Chem 21(11) 3147-53 6/1/2013
  • Mims A, Walker AR, Huang X, Sun J, Wang H, Santhanam R, Dorrance AM, Walker C, Hoellerbauer P, Tarighat SS, Chan KK, Klisovic RB, Perrotti D, Caligiuri MA, Byrd JC, Chen CS, Lee LJ, Jacob S, Mrózek K, Bloomfield CD, Blum W, Garzon R, Schwind S, Marcucci GIncreased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia.Leukemia 27(4) 871-8 4/1/2013
  • Yan P, Frankhouser D, Murphy M, Tam HH, Rodriguez B, Curfman J, Trimarchi M, Geyer S, Wu YZ, Whitman SP, Metzeler K, Walker A, Klisovic R, Jacob S, Grever MR, Byrd JC, Bloomfield CD, Garzon R, Blum W, Caligiuri MA, Bundschuh R, Marcucci GGenome-wide methylation profiling in decitabine-treated patients with acute myeloid leukemia.Blood 120(12) 2466-74 9/20/2012
  • Yu B, Hsu SH, Zhou C, Wang X, Terp MC, Wu Y, Teng L, Mao Y, Wang F, Xue W, Jacob ST, Ghoshal K, Lee RJ, Lee LJLipid nanoparticles for hepatic delivery of small interfering RNA.Biomaterials 33(25) 5924-34 9/1/2012
  • Hsu SH, Wang B, Kota J, Yu J, Costinean S, Kutay H, Yu L, Bai S, La Perle K, Chivukula RR, Mao H, Wei M, Clark KR, Mendell JR, Caligiuri MA, Jacob ST, Mendell JT, Ghoshal KEssential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver.J Clin Invest 122(8) 2871-83 8/1/2012
  • Wang B, Hsu S, Frankel W, Ghoshal K, Jacob STStat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha.Hepatology 56(1) 186-97 7/1/2012
  • Blum W, Schwind S, Tarighat SS, Geyer S, Eisfeld AK, Whitman S, Walker A, Klisovic R, Byrd JC, Santhanam R, Wang H, Curfman JP, Devine SM, Jacob S, Garr C, Kefauver C, Perrotti D, Chan KK, Bloomfield CD, Caligiuri MA, Grever MR, Garzon R, Marcucci GClinical and pharmacodynamic activity of bortezomib and decitabine in acute myeloid leukemia.Blood 119(25) 6025-31 6/21/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu