John Phay MD

John Phay MD
Assoc Professor - ClinicalCollege of
N924 Doan Hall 410 W 10th Avenue Columbus Ohio 43210
Phone:614-293-8550Fax: 614-293-3465
  • Molecular Biology and Cancer Genetics

Research Description

Dr. Phay has two main research projects. The first is examining a novel AMPK activator for the treatment of thyroid cancer. Dr. Phay's research has shown in multiple human thyroid cancer cell lines that OSU-53 has inhibited growth at concentrations equal or lower than in breast cancer cells, and a dose and time-dependent activation of AMPK. He is currently studying the mechanism of action to potentially use synergistically with known BRAF inhibitors. The second research project is creating a molecular imaging agent for medullary thyroid cancer (MTC) and parathyroid tumors. The calcium sensing-receptor (CaSR) is expressed primarily on parathyroids, thyroid C-cells, and the kidney, as well as in MTC. Further development may allow pre-operative and intra-operative detection to improve surgical outcomes.

Current Publications

  • Phay JE, Ringel MDMetastatic mechanisms in follicular cell-derived thyroid cancer.Endocr Relat Cancer 20 R307-19 12/1/2013
  • Yusof AM, Kothandaraman S, Zhang X, Saji M, Ringel MD, Tweedle MF, Phay JEDevelopment of a calcium-sensing receptor molecular imaging agent.Surgery 154 1378-84; discussion 1384 12/1/2013
  • McWade MA, Paras C, White LM, Phay JE, Mahadevan-Jansen A, Broome JTA novel optical approach to intraoperative detection of parathyroid glands.Surgery 154 1371-7; discussion 1377 12/1/2013
  • Ding H, Yusof AM, Kothandaraman S, Saji M, Wang C, Kumar K, Milum K, Carleton M, Pan X, Ringel MD, Tweedle MF, Phay JELocalization of CaSR antagonists in CaSR-expressing medullary thyroid cancer.J Clin Endocrinol Metab 98 E1722-9 11/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: