Xiaoming (Shawn) He PhD

Xiaoming (Shawn) He PhD
Assoc ProfessorCollege of Engineeringhe.429@osu.eduwebsite
296 Bevis Hall 1080 Carmack Road Columbus Ohio 43210
Phone:614-247-8759Fax: (614) 292-7301
  • Translational Therapeutics

General Research Interest

Micro- and nano-sale biomaterials and systems for drug, gene, cell, and tissue delivery; energy-based thermo and cryo ablation or therapy

Research Description

The research in my lab has been focused on developing (1) novel micro and nano scale biomaterials and systems with great biocompatibility for improved drug, gene, cell, and tissue delivery and (2) energy-based approaches (using both cold and heat generated with microwave, radio frequency, laser, and ultrasound) for minimally invasive ablation of diseased tissue in situ. Our research has a variety of practical applications including but not limited to cancer treatment, transplantation, regenerative, and reproductive medicine. Our research in cancer treatment has been supported by the Wendy Will Case Cancer Fund and American Cancer Society (Research Scholar Grant).

Transinstitutional Work

We have been collaborating with Prof. Xiongbin Lu at the University of Texas MD Anderson Cancer Center to develop combined approaches for improved cancer treatment.

Current Publications

  • Caligiuri MA, Yu J, Deng Y, Chu J, Ren Y, Fan Z, Ji X, Mundy-Bosse B, Yuan S, Hughes T, Zhang J, Cheema B, Camardo AT, Xia Y, Wu LC, Wang LS, He X, Kinghorn AD, Li XThe Natural Product Phyllanthusmin C Enhances IFN-γ Production by Human NK Cells through Upregulation of TLR-Mediated NF-κB Signaling.J Immunol 193 9/15/2014
  • Rao W, Zhao S, Yu J, Lu X, Zynger DL, He XEnhanced enrichment of prostate cancer stem-like cells with miniaturized 3D culture in liquid core-hydrogel shell microcapsules.Biomaterials 35 7762-73 9/1/2014
  • Chu J, He S, Deng Y, Zhang J, Peng Y, Hughes T, Yi L, Kwon CH, Wang QE, Devine SM, He X, Bai XF, Hofmeister CC, Yu JGenetic modification of T cells redirected toward CS1 enhances eradication of myeloma cells.Clin Cancer Res 20 3989-4000 8/1/2014
  • Devine SM, Zhang X, Caligiuri MA, Hofmeister CC, Yu J, Chu J, Deng Y, Benson DM, He S, Hughes T, Zhang J, Peng Y, Mao H, Yi L, Ghoshal K, He XCS1-specific chimeric antigen receptor (CAR)-engineered natural killer cells enhance in vitro and in vivo antitumor activity against human multiple myeloma.Leukemia 28 917-27 4/1/2014
  • Yi J, Liang XM, Zhao G, He XAn improved model for nucleation-limited ice formation in living cells during freezing.PLoS One 9 e98132 1/1/2014
  • Agarwal P, Zhao S, Bielecki P, Rao W, Choi JK, Zhao Y, Yu J, Zhang W, He XOne-step microfluidic generation of pre-hatching embryo-like core-shell microcapsules for miniaturized 3D culture of pluripotent stem cells.Lab Chip 13 4525-33 12/7/2013
  • Choi JK, Agarwal P, He XIn vitro culture of early secondary preantral follicles in hanging drop of ovarian cell-conditioned medium to obtain MII oocytes from outbred deer mice.Tissue Eng Part A 19 2626-37 12/1/2013
  • Yu J, He S, Chu J, Wu LC, Mao H, Peng Y, Alvarez-Breckenridge CA, Hughes T, Wei M, Zhang J, Yuan S, Sandhu S, Vasu S, Benson DM Jr, Hofmeister CC, He X, Ghoshal K, Devine SM, Caligiuri MAMicroRNAs activate natural killer cells through Toll-like receptor signaling.Blood 121 4663-71 6/6/2013
  • He X, Choi JKIn vitro maturation of cumulus-oocyte complexes for efficient isolation of oocytes from outbred deer mice.PLoS One 8 e56158 1/1/2013
  • Yu J, Peng Y, Wu LC, Xie Z, Deng Y, Hughes T, He S, Mo X, Chiu M, Wang QE, He X, Liu S, Grever MR, Chan KK, Liu ZCurcumin down-regulates DNA methyltransferase 1 and plays an anti-leukemic role in acute myeloid leukemia.PLoS One 8 e55934 1/1/2013
  • Zhang W, Zhao S, Rao W, Snyder J, Choi JK, Wang J, Khan IA, Saleh NB, Mohler PJ, Yu J, Hund TJ, Tang C, He XA Novel Core-Shell Microcapsule for Encapsulation and 3D Culture of Embryonic Stem Cells.J Mater Chem B Mater Biol Med 2013 1002-1009 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu