Jeffrey Chalmers J PhD

Jeffrey Chalmers J PhD
ProfessorCollege of Engineeringchalmers.1@osu.edu
333B Koffolt Laboratories 140 W 19th Avenue Columbus Ohio 43210
Phone:614-292-2727Fax: (614) 292-3769
  • Translational Therapeutics

General Research Interest

Bioengineering, Biochemical Engineering, Biomedical Engineering

Research Description

The research conducted in laboratories that I oversee involved the development of fundamental understanding and applications of the interaction of hydrodynamic and magnetic forces and cells.  This work can range from the development of fundamental mathematical relationship describing physical phenomena to the development of simple, robust instruments for use in a clinical setting. 

Transinstitutional Work

The Chalmers laboratory, in collaboration with Dr. Maciej Zborowski are developing magnetic cell separation instrumentation that is being used in collaboration with several clinical laboratories at the Cleveland Clinic and The James Cancer Hospital to detect circulating tumor cells in the blood of cancer patients.

Current Publications

  • Mathsyaraja H, Thies K, Taffany DA, Deighan C, Liu T, Yu L, Fernandez SA, Shapiro C, Otero J, Timmers C, Lustberg MB, Chalmers J, Leone G, Ostrowski MCCSF1-ETS2-induced microRNA in myeloid cells promote metastatic tumor growth.Oncogene in press 9/22/2014
  • Zborowski M, Moore LR, Williams PS, Nehl F, Abe K, Chalmers JJFeasibility study of red blood cell debulking by magnetic field-flow fractionation with step-programmed flow.Anal Bioanal Chem 406 1661-70 2/1/2014
  • Lustberg MB, Balasubramanian P, Miller B, Garcia-Villa A, Deighan C, Wu Y, Carothers S, Berger M, Ramaswamy B, Macrae ER, Wesolowski R, Layman RM, Mrozek E, Pan X, Summers TA, Shapiro CL, Chalmers JJHeterogeneous atypical cell populations are present in blood of metastatic breast cancer patients.Breast Cancer Res 16 R23 1/1/2014
  • Miller BL, Balasubramanian P, Lustberg MB, Wu Y, Deighan CJ, Zborowski M, Chalmers JJIsolation and analysis of rare cells in the blood of cancer patients using a negative depletion methodology.Methods 64 169-82 12/1/2013
  • Chen A, Byvank T, Chang WJ, Bharde A, Vieira G, Miller BL, Chalmers JJ, Bashir R, Sooryakumar ROn-chip magnetic separation and encapsulation of cells in droplets.Lab Chip 13 1172-81 3/21/2013
  • Moore LR, Nehl F, Dorn J, Chalmers JJ, Zborowski MOpen Gradient Magnetic Red Blood Cell Sorter Evaluation on Model Cell Mixtures.IEEE Trans Magn 49 309-315 2/1/2013
  • Xu J, Mahajan K, Xue W, Winter JO, Zborowski M, Chalmers JJSimultaneous, single particle, magnetization and size measurements of micron sized, magnetic particles.J Magn Magn Mater 324 4189-4199 12/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu