Craig Forsyth J PhD

Craig Forsyth J PhD
ProfessorCollege of Arts & Sciencesforsyth.14@osu.eduwebsite
1054 Evans Laboratory 88 W 18th Avenue Columbus Ohio 43210
Phone:614-688-5347Fax:
  • Non-Member

Research Description

The general theme of our research is the synthesis of complex, biologically active organic molecules based upon natural product templates. Natural product targets are chosen that provide maximal synergy among the implementation of synthetic strategies, the development of new methods, and the potential for biological applications. Although target oriented complex molecule synthesis is emphasized, enabling synthetic methods derive from particular challenges encountered in the pursuit of novel tactics and strategies. Current projects span various structural classes and biological activities of the synthetic targets. These include protein serine / threonine phosphatase inhibitors based upon members of the okadaic acid class, the potent anticancer natural product phorboxazole A, the marine biotoxin azaspiracid, and a variety of smaller molecules.

Current Publications

  • Zhang Z, Ding Y, Xu J, Chen Y, Forsyth CJSynthesis of the C1-C21 domain of azaspiracids-1 and -3.Org Lett 15 2338-41 5/17/2013
  • Butler SC, Forsyth CJA stereoconvergent intramolecular Diels-Alder cycloaddition related to the construction of the decalin core of neo-clerodane diterpenoids.J Org Chem 78 3895-907 4/19/2013
  • Wu D, Forsyth CJSyntheses of the C1-C14 and C15-C25 fragments of amphidinolide C.Org Lett 15 1178-81 3/15/2013
  • Gao Y, Vogt A, Forsyth CJ, Koide KComparison of splicing factor 3b inhibitors in human cells.Chembiochem 14 49-52 1/2/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu