Research DescriptionOur research program is focussed on both the fundamental and applied aspects of organic chemistry at interfaces, particularly lipid membranes. We are pursuing new tools to illuminate lipid membrane biophysics and for controlled chemical delivery to living cells and tissues. Membrane transformations are used in Nature to control the release of chemical agents to designated in vivo targets; we seek to design synthetic lipid and polymer systems that will deliver chemical cargo in a similarly selective manner, predicated on an understanding of lipid assembly biophysics.
Research in the group is highly multidisciplinary: projects begins with organic synthesis and branch into biophysics, bioanalytical studies and cell biology. Researchers with these diverse backgrounds work together to investigate interfacial molecular recognition and its applications in biotechnology and materials science. To this end, our group pursues research in the design and organic synthesis of simple but potentially biologically interesting lipids, peptides, polymers and membrane assemblies.