Michael Freitas A PhD

Michael Freitas A PhD
Assoc ProfessorCollege of Medicinefreitas.5@osu.edu
906 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-688-8432Fax: (614) 292-0559
  • Molecular Biology and Cancer Genetics

Research Description

Dr. Freitas' lab has developed extensive expertise in the field of clinical/translational proteomics, biomarker discovery/validation and bioinformatics for mass spectrometry based proteomics. Their work focuses on the determination of side chain modifications of proteins important in Chromatin Remodeling and relating these modifications to aberrant cellular function in cancer.

Current Publications

  • Kobayashi K, Katz A, Rajkovic A, Ishii R, Branson OE, Freitas MA, Ishitani R, Ibba M, Nureki OThe non-canonical hydroxylase structure of YfcM reveals a metal ion-coordination motif required for EF-P hydroxylation.Nucleic Acids Res in press 10/1/2014
  • Harshman SW, Hoover ME, Huang C, Branson OE, Chaney SB, Cheney CM, Rosol TJ, Shapiro CL, Wysocki VH, Huebner K, Freitas MAHistone h1 phosphorylation in breast cancer.J Proteome Res 13 2453-67 5/2/2014
  • Guan X, Rastogi N, Parthun MR, Freitas MASILAC peptide ratio calculator: a tool for SILAC quantitation of peptides and post-translational modifications.J Proteome Res 13 506-16 2/7/2014
  • Harshman SW, Young NL, Parthun MR, Freitas MAH1 histones: current perspectives and challenges.Nucleic Acids Res 41 9593-609 11/1/2013
  • Singh R, Mortazavi A, Telu KH, Nagarajan P, Lucas DM, Thomas-Ahner JM, Clinton SK, Byrd JC, Freitas MA, Parthun MRIncreasing the complexity of chromatin: functionally distinct roles for replication-dependent histone H2A isoforms in cell proliferation and carcinogenesis.Nucleic Acids Res 41 9284-95 11/1/2013
  • Harshman SW, Chen MM, Branson OE, Jacob NK, Johnson AJ, Byrd JC, Freitas MAIsolation and analysis of linker histones across cellular compartments.J Proteomics 91 595-604 10/8/2013
  • Smith EM, Talabere T, Efebera YA, Hofmeister CC, Benson DM Jr, Paulaitis ME, Freitas MA, Pichiorri F, Harshman SW, Canella A, Ciarlariello PD, Rocci A, Agarwal KCharacterization of multiple myeloma vesicles by label-free relative quantitation.Proteomics 13 3013-29 10/1/2013
  • Guan X, Rastogi N, Parthun MR, Freitas MADiscovery of histone modification crosstalk networks by stable isotope labeling of amino acids in cell culture mass spectrometry (SILAC MS).Mol Cell Proteomics 12 2048-59 8/1/2013
  • Ge Z, Nair D, Guan X, Rastogi N, Freitas MA, Parthun MRSites of acetylation on newly synthesized histone H4 are required for chromatin assembly and DNA damage response signaling.Mol Cell Biol 33 3286-98 8/1/2013
  • Hsu SH, Motiwala T, Roy S, Claus R, Mustafa M, Plass C, Freitas MA, Ghoshal K, Jacob STMethylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate.J Cell Biochem 114 1810-8 8/1/2013
  • Telu KH, Abbaoui B, Thomas-Ahner JM, Zynger DL, Clinton SK, Freitas MA, Mortazavi AAlterations of histone H1 phosphorylation during bladder carcinogenesis.J Proteome Res 12 3317-26 7/5/2013
  • Sutton GM, Ptitsyn AA, Floyd ZE, Yu G, Wu X, Hamel K, Shah FS, Centanni A, Eilertsen K, Kheterpal I, Newman S, Leonardi C, Freitas MA, Bunnell BA, Gimble JMBiological aging alters circadian mechanisms in murine adipose tissue depots.Age (Dordr) 35 533-47 6/1/2013
  • Byrd JC, Pichiorri F, Palmieri D, De Luca L, Consiglio J, You J, Rocci A, Talabere T, Piovan C, Lagana A, Cascione L, Guan J, Gasparini P, Balatti V, Nuovo G, Coppola V, Hofmeister CC, Marcucci G, Volinia S, Shapiro CL, Freitas MA, Croce CMIn vivo NCL targeting affects breast cancer aggressiveness through miRNA regulation.J Exp Med 210 951-68 5/6/2013
  • Luechapanichkul R, Chen X, Taha HA, Vyas S, Guan X, Freitas MA, Hadad CM, Pei DSpecificity profiling of dual specificity phosphatase vaccinia VH1-related (VHR) reveals two distinct substrate binding modes.J Biol Chem 288 6498-510 3/1/2013
  • Shapiro JP, Biswas S, Merchant AS, Satoskar A, Taslim C, Lin S, Rovin BH, Sen CK, Roy S, Freitas MAA quantitative proteomic workflow for characterization of frozen clinical biopsies: laser capture microdissection coupled with label-free mass spectrometry.J Proteomics 77 433-40 12/21/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu