Michael V. Knopp MD, PhD

Michael V. Knopp MD, PhD
ProfessorCollege of Medicineknopp.16@osu.edu
430 Twelfth Avenue, 395 West 395 W 12th Avenue Columbus Ohio 43210
Phone:614-293-9998Alternate Phone:614-293-9227Fax: 614-293-9275
  • Translational Therapeutics

General Research Interest

Oncological imaging for detection of disease characterization, staging, therapy planning and response assessment; imaging-based assessment of neoangiogenesis; imaging biomarker; semi-quantitative imaging

Research Description

The broad research activities focus on imaging biomarker for disease characterization and response assessment, imaging technology development and validation, imaging biomarker development and validation.

Transinstitutional Work

The research projects are consolidated under the Wright Center of Innovation in Biomedical Imaging which is a unique trans-institutional, interdisciplinary, academia/industry imaging technology development service and commercialization environment. Collaboration in all areas of health and biological sciences and engineering, arts and sciences and business are ongoing.

Current Publications

  • Mrózek E, Layman R, Ramaswamy B, Lustberg M, Vecchione A, Knopp MV, Shapiro CLPhase II Trial of Neoadjuvant Weekly Nanoparticle Albumin-Bound Paclitaxel, Carboplatin, and Biweekly Bevacizumab Therapy in Women With Clinical Stage II or III HER2-Negative Breast Cancer.Clin Breast Cancer 14 228-34 8/1/2014
  • Nguyen HT, Jia G, Shah ZK, Pohar K, Mortazavi A, Zynger DL, Wei L, Yang X, Clark D, Knopp MVPrediction of chemotherapeutic response in bladder cancer using K-means clustering of dynamic contrast-enhanced (DCE)-MRI pharmacokinetic parameters.J Magn Reson Imaging in press 6/19/2014
  • Nguyen HT, Pohar KS, Jia G, Shah ZK, Mortazavi A, Zynger DL, Wei L, Clark D, Yang X, Knopp MVImproving bladder cancer imaging using 3-T functional dynamic contrast-enhanced magnetic resonance imaging.Invest Radiol 49 390-5 6/1/2014
  • Campbell AB, Quatman CE, Schmitt LC, Knopp MV, Flanigan DCIs magnetic resonance imaging assessment of the size of articular cartilage defects accurate?J Knee Surg 27 67-75 2/1/2014
  • Wei W, Jia G, Flanigan D, Zhou J, Knopp MVChemical exchange saturation transfer MR imaging of articular cartilage glycosaminoglycans at 3 T: Accuracy of B0 Field Inhomogeneity corrections with gradient echo method.Magn Reson Imaging 32 41-7 1/1/2014
  • McLoney ED, Krishnasamy VP, Castle JC, Yang X, Guy GComplications of Celect, Günther tulip, and Greenfield inferior vena cava filters on CT follow-up: a single-institution experience.J Vasc Interv Radiol 24 1723-9 11/1/2013
  • Christoforidis JB, Williams MM, Epitropoulos FM, Knopp MVSubconjunctival bleb that forms at the injection site after intravitreal injection is drug, not vitreous.Clin Experiment Ophthalmol 41 614-5 8/1/2013
  • Sammet CL, Yang X, Wassenaar PA, Bourekas EC, Yuh BA, Shellock F, Sammet S, Knopp MVRF-related heating assessment of extracranial neurosurgical implants at 7T.Magn Reson Imaging 31 1029-34 7/1/2013
  • Stamm AC, Wright CL, Knopp MV, Schmalbrock P, Heverhagen JTPhase contrast and time-of-flight magnetic resonance angiography of the intracerebral arteries at 1.5, 3 and 7 T.Magn Reson Imaging 31 545-9 5/1/2013
  • Christoforidis JB, Williams MM, Wang J, Jiang A, Pratt C, Abdel-Rasoul M, Hinkle GH, Knopp MVAnatomic and pharmacokinetic properties of intravitreal bevacizumab and ranibizumab after vitrectomy and lensectomy.Retina 33 946-52 5/1/2013
  • Hall NC, Povoski SP, Zhang J, Knopp MV, Martin EWUse of intraoperative nuclear medicine imaging technology: strategy for improved patient management.Expert Rev Med Devices 10 149-52 3/1/2013
  • Campbell AB, Knopp MV, Kolovich GP, Wei W, Jia G, Siston RA, Flanigan DCPreoperative MRI underestimates articular cartilage defect size compared with findings at arthroscopic knee surgery.Am J Sports Med 41 590-5 3/1/2013
  • Povoski SP, Hall NC, Murrey DA, Sharp DS, Hitchcock CL, Mojzisik CM, Bahnson EE, Knopp MV, Martin EW, Bahnson RRMultimodal imaging and detection strategy with 124 I-labeled chimeric monoclonal antibody cG250 for accurate localization and confirmation of extent of disease during laparoscopic and open surgical resection of clear cell renal cell carcinoma.Surg Innov 20 59-69 2/1/2013
  • Fitzgerald TJ, Bishop-Jodoin M, Bosch WR, Curran WJ, Followill DS, Galvin JM, Hanusik R, King SR, Knopp MV, Laurie F, O'Meara E, Michalski JM, Saltz JH, Schnall MD, Schwartz L, Ulin K, Xiao Y, Urie MFuture vision for the quality assurance of oncology clinical trials.Front Oncol 3 31 1/1/2013
  • Nowinski WL, Puspitasaari F, Volkau I, Marchenko Y, Knopp MVComparison of magnetic resonance angiography scans on 1.5, 3, and 7 Tesla units: a quantitative study of 3-dimensional cerebrovasculature.J Neuroimaging 23 86-95 1/1/2013
  • Nowinski WL, Puspitasari F, Volkau I, Orrison WW, Knopp MVQuantification of the human cerebrovasculature: a 7Tesla and 320-row CT in vivo study.J Comput Assist Tomogr 37 117-22 1/1/2013
  • Christoforidis JB, Wassenaar PA, Christoforidis GA, Ho VY, Knopp MV, Schmalbrock PMRetrobulbar vasculature using 7-T magnetic resonance imaging with dedicated eye surface coil.Graefes Arch Clin Exp Ophthalmol 251 271-7 1/1/2013
  • Christoforidis JB, Williams MM, Kothandaraman S, Kumar K, Epitropoulos FJ, Knopp MVPharmacokinetic properties of intravitreal I-124-aflibercept in a rabbit model using PET/CT.Curr Eye Res 37 1171-4 12/1/2012
  • Erdal BS, Crouser ED, Yildiz V, King MA, Patterson AT, Knopp MV, Clymer BDQuantitative computerized two-point correlation analysis of lung CT scans correlates with pulmonary function in pulmonary sarcoidosis.Chest 142 1589-97 12/1/2012
  • Martin LK, Grecula J, Jia G, Wei L, Yang X, Otterson GA, Wu X, Harper E, Kefauver C, Zhou BS, Yen Y, Bloomston M, Knopp M, Ivy SP, Grever M, Bekaii-Saab TA dose escalation and pharmacodynamic study of triapine and radiation in patients with locally advanced pancreas cancer.Int J Radiat Oncol Biol Phys 84 e475-81 11/15/2012
  • Harris JD, Brophy RH, Jia G, Price B, Knopp M, Siston RA, Flanigan DCSensitivity of magnetic resonance imaging for detection of patellofemoral articular cartilage defects.Arthroscopy 28 1728-37 11/1/2012
  • Kocak E, Carruthers KH, Knopp MV, Carkaci S, Martin EW, Povoski SPImage-guided technologies to facilitate the dissection of microsurgical autologous tissue-free flaps.Expert Rev Med Devices 9 547-9 11/1/2012
  • Yang X, Mrozek E, Lustberg M, Jia G, Sammet S, Sammet C, Shapiro C, Knopp MVMicrocirculatory fraction (MCF(I)) as a potential imaging marker for tumor heterogeneity in breast cancer.Magn Reson Imaging 30 1059-67 10/1/2012
  • Bluestein KT, Pitt D, Sammet S, Zachariah CR, Nagaraj U, Knopp MV, Schmalbrock PDetecting cortical lesions in multiple sclerosis at 7 T using white matter signal attenuation.Magn Reson Imaging 30 907-15 9/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu