Molecular Carcinogenesis and Chemoprevention

The Molecular Carcinogenesis and Chemoprevention (MCC) is one of OSUCCC–James' five highly interactive cancer research programs. The programs comprise more than 200 leading scientists from 13 different colleges within OSU and affiliated academic institutions.

Devoted to scientific excellence and specifically tailored to capitalize on the professional strengths and expertise of its members, MCC members’ research focuses on molecular carcinogenesis, bionutrition, translational chemoprevention and dietary prevention research.

The MCC’s primary goal is to elucidate molecular and cellular mechanisms that underlie carcinogenesis and to develop novel strategies for cancer prevention via chemoprevention and nutrition.

To achieve this, the MCC’s objectives are to:

  • Characterize molecular and cellular changes induced by chemical, physical, hormonal and infectious agents that contribute to neoplastic transformation and multistage carcinogenesis in experimental models and humans
  • Develop and characterize novel agents for cancer chemoprevention and define the efficacy, safety and mechanisms of action using in vitro and preclinical models
  • Identify dietary and nutritional components that may enhance or inhibit the carcinogenesis cascade
  • Implement translational prevention studies in human populations with an emphasis on those at risk due to exposure to carcinogenic or cancer promoting agents, familial and genetic predisposition, or due to the presence of premalignant lesions.

Leaders: Steven Clinton, MD, PhD

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu