Sissy Jhiang M PhD

Sissy Jhiang M PhD
ProfessorCollege of
210 Hamilton Hall 1645 Neil Avenue Columbus Ohio 43210
Phone:614-292-4312Fax: (614) 292-4888
  • Molecular Biology and Cancer Genetics

General Research Interest

genetic-engineered mouse models for thyroid tumorigenesis, anatomic/functional imaging in pre-clinical mouse models, sodium-iodide symporter targeted imaging and radionuclide therapy in thyroid cancer and breast cancer, mechanobiology during cancer metastasis.

Research Description

Dr Jhiang current research interests are: (a) examine RET/PTC mediated signaling pathways in thyroid tumorigenesis and apply the finding to improve patients' care; (b) Investigate regulatory mechanisms of Na+/I- symporter(NIS) in thyroid cancer and breast cancer and apply the finding to develop strategies for radionuclide imaging and effective targeted therapy; (c) NIS as an imaging reporter gene to monitor gene delivery in gene therapy clinical trials; and (d) mechanobiology characterization in the process of cancer metastasis using one-of-the-kind instruments based on atomic force microscopy, magnetic tweezer, and photonic force microscopy (in collaboration with Dr. CH Menq at the Department of Mechanical Engineering). Thus, Dr. Jhiang's research areas involved in molecular biology, cellular biology, genetic engineered animal models, small animal imaging modalities, and nanobiotechnology.

Transinstitutional Work

thyroid cancer animal models as well as sodium iodide symporter DNA construcs have been requested by multiple institutes nationally and internationally. active collaborations within OSU: (1) thyroid cancer NCI funded program project, and (b) mechanobiology in cancer metastasis

Current Publications

  • Lakshmanan A, Wojcicka A, Kotlarek M, Zhang X, Jazdzewski K, Jhiang SmicroRNA-339-5p modulates Na+/I- symporter-mediated radioiodide uptake.Endocr Relat Cancer in press 11/17/2014
  • Lakshmanan A, Scarberry D, Shen DH, Jhiang SMModulation of Sodium Iodide Symporter in Thyroid Cancer.Horm Cancer in press 9/19/2014
  • Lakshmanan A, Doseff AI, Ringel MD, Saji M, Rousset B, Zhang X, Jhiang SMApigenin in combination with Akt inhibition significantly enhances thyrotropin-stimulated radioiodide accumulation in thyroid cells.Thyroid 24 878-87 5/1/2014
  • Wang Y, Jeong Y, Jhiang SM, Yu L, Menq CHQuantitative Characterization of Cell Behaviors through Cell Cycle Progression via Automated Cell Tracking.PLoS One 9 e98762 1/1/2014
  • La Perle KM, Kim DC, Hall NC, Bobbey A, Shen DH, Nagy RS, Wakely PE Jr, Lehman A, Jarjoura D, Jhiang SMModulation of sodium/iodide symporter expression in the salivary gland.Thyroid 23 1029-36 8/1/2013
  • Zhang Z, Beyer S, Jhiang SMMEK inhibition leads to lysosome-mediated Na+/I- symporter protein degradation in human breast cancer cells.Endocr Relat Cancer 20 241-50 4/1/2013
  • Qian Z, Liu T, Liu YY, Briesewitz R, Barrios AM, Jhiang SM, Pei DEfficient delivery of cyclic peptides into mammalian cells with short sequence motifs.ACS Chem Biol 8 423-31 2/15/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: