General Research InterestCancer biology and Immunology
Research DescriptionThe fundamental interest of Dr. Wang's labe is to understand how eukaryotic cell integrates various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell signaling programs on cell fate determination in the context of tumorigenesis and immunity. We apply various experimental models, each one of these has unique scientific features, to address our questions. To name few, the mouse models of human tumor and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessible for direct intracellular injection of biological material), various primary cells from mouse (MEFs, T, B cell and macrophage) and human transformed cell lines (provide unique cellular tools to understand the potential cellular mechanisms that may mimic what happen in vivo).