Christin E Burd PhD


Christin E Burd PhD
Asst ProfessorArts and Sciencesburd.25@osu.edu
Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-688-7569Fax: 614-688-4245
  • Molecular Biology and Cancer Genetics

General Research Interest

The Role of the INK4/ARF locus in cancer and aging

Research Description

The INK4/ARF locus encodes three tumor suppressor genes frequently lost or silenced in human cancers (p15INK4b, p16INK4a, and p14ARF). We aim to faithfully recapitulate the genetics of these tumors through the development of genetically engineered mouse models. In addition, we have pioneered in vivo imaging techniques that allow us to track the formation and progression of spontaneous cancers. Use of these technologies will provide mechanistic insight into the molecular processes governing tumor initiation, progression and therapeutic resistance. It is our goal to bridge the gap between bench science and clinical trials, generating faithful models for drug discovery and efficacy studies.

Current Publications

  • Sharpless NETargeted Next Generation Sequencing Identifies Clinically Actionable Mutations in Patients with Melanoma.Pigment Cell Melanoma Res 3/15/2014
  • Lapak KM, Burd CEThe molecular balancing act of p16(INK4a) in cancer and aging.Mol Cancer Res 12 167-83 2/1/2014
  • Sharpless NEp16INK4a reporter mice reveal age-promoting effects of environmental toxicants.J Clin Invest 124 169-73 1/2/2014
  • Burd CE, Sorrentino JA, Clark KS, Darr DB, Krishnamurthy J, Deal AM, Bardeesy N, Castrillon DH, Beach DH, Sharpless NEMonitoring tumorigenesis and senescence in vivo with a p16(INK4a)-luciferase model.Cell 152(1-2) 340-51 1/17/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu