General Research InterestMicroenvironmental determinants of tumor metabolism and growth.
Research DescriptionThe dysfunctional tumor vasculature and the deregulated cancer cell proliferation create areas of oxygen- and nutrient- deprivation in solid tumors. Cells within the tumor respond to these microenvironmental stresses by activating adaptive mechanisms that allow malignant progression under such harsh conditions. Dr. Papandreou is investigating stress-modulated transcriptional and biochemical pathways, with particular emphasis given to the reprogramming of glucose and lipid metabolism under hypoxic environments. Her research employs in vitro models of hypoxia and hypoglycemia, tumor xenotransplantation protocols and genetically engineered mouse models with the goal to identify new targets for therapeutic development.