Paul Goodfellow J PhD


Paul Goodfellow J PhD
ProfessorCollege of Medicinegoodfellow.12@osu.edu
808 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-685-6911Fax:
  • Molecular Biology and Cancer Genetics

Research Description

Dr. Goodfellow’s research focuses on understanding the role that loss of DNA mismatch repair plays in tumor initiation and progression and understanding key molecular events that can be used to develop novel approaches to the prevention and treatment of endometrial cancers.

Current Publications

  • Zhang B, Xing X, Li J, Lowdon RF, Zhou Y, Lin N, Zhang BX, Sundaram V, Chiappinelli KB, Hagemann IS, Mutch DG, Goodfellow PJ, Wang TComparative DNA methylome analysis of endometrial carcinoma reveals complex and distinct deregulation of cancer promoters and enhancers.BMC Genomics in press 10/6/2014
  • Billingsley CC, Cohn DE, Mutch DG, Stephens JA, Suarez AA, Goodfellow PJPolymerase ɛ (POLE) mutations in endometrial cancer: Clinical outcomes and implications for Lynch syndrome testing.Cancer in press 9/15/2014
  • Tierney BJ, McCann GA, Naidu S, Rath KS, Saini U, Wanner R, Kuppusamy P, Suarez A, Goodfellow PJ, Cohn DE, Selvendiran KAberrantly activated pSTAT3-Ser727 in human endometrial cancer is suppressed by HO-3867, a novel STAT3 inhibitor.Gynecol Oncol in press 7/16/2014
  • Powell MA, Sill MW, Goodfellow PJ, Benbrook DM, Lankes HA, Leslie KK, Jeske Y, Mannel RS, Spillman MA, Lee PS, Hoffman JS, McMeekin DS, Pollock PMA phase II trial of brivanib in recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology Group Study.Gynecol Oncol in press 7/11/2014
  • Huang YW, Kuo CT, Chen JH, Goodfellow PJ, Huang TH, Rader JS, Uyar DSHypermethylation of miR-203 in endometrial carcinomas.Gynecol Oncol 133 340-5 5/1/2014
  • Purrington KS, Slager S, Eccles D, Yannoukakos D, Fasching PA, Miron P, Carpenter J, Chang-Claude J, Martin NG, Montgomery GW, Kristensen V, Anton-Culver H, Goodfellow P, Tapper WJ, Rafiq S, Clarke C, Pathmanathan N, Rudolph A, Flesch-Janys D, Nickels S, Olson JE, Ingle JN, Olswold C, Slettedahl S, Eckel-Passow JE, Anderson SK, Visscher DW, Cafourek VL, Sicotte H, Prodduturi N, Weiderpass E, Bernstein L, Ziogas A, Ivanovich J, Giles GG, Baglietto L, Southey M, Kosma VM, Fischer HP, GENICA Network, Reed MW, Mannermaa A, Easton D, Hall P, Brauch H, Cox A, Zheng W, Godwin AK, Hamann U, Ambrosone C, Toland AE, Nevanlinna H, Vachon CM, Couch FJ, Gerty SM, Durcan L, Konstantopoulou I, Fostira F, Vratimos A, Apostolou P, Konstanta I, Kotoula V, Lakis S, Dimopoulos MA, Skarlos D, Pectasides D, Fountzilas G, Beckmann MW, Hein A, Ruebner M, Ekici AB, Hartmann A, Schulz-Wendtland R, Renner SP, Janni W, Rack B, Scholz C, Neugebauer J, Andergassen U, Lux MP, Haeberle L, Cross SS, Deming-Halverson S, Shrubsole M, Cai Q, Shu XO, Daly M, Weaver J, Ross E, Klemp J, Sharma P, Torres D, Rüdiger T, Wölfing H, Ulmer HU, Försti A, Khoury T, Kumar S, Pilarski R, Shapiro CL, Greco D, Heikkilä P, Aittomäki K, Blomqvist C, Irwanto A, Liu J, Pankratz VS, Wang X, Severi GGenome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.Carcinogenesis 35 1012-9 5/1/2014
  • Suarez AA, Joehlin-Price AS, Perrino CM, Stephens J, Backes FJ, Goodfellow PJ, Cohn DEMismatch repair protein expression in 1049 endometrial carcinomas, associations with body mass index, and other clinicopathologic variables.Gynecol Oncol 133 43-7 4/1/2014
  • Zighelboim I, Mutch DG, Knapp A, Ding L, Xie M, Cohn DE, Goodfellow PJHigh frequency strand slippage mutations in CTCF in MSI-positive endometrial cancers.Hum Mutat 35 63-5 1/1/2014
  • McConechy MK, Ding J, Senz J, Yang W, Melnyk N, Tone AA, Prentice LM, Wiegand KC, McAlpine JN, Shah SP, Lee CH, Goodfellow PJ, Gilks CB, Huntsman DGOvarian and endometrial endometrioid carcinomas have distinct CTNNB1 and PTEN mutation profiles.Mod Pathol 27 128-34 1/1/2014
  • Kanchi KL, Johnson KJ, Lu C, McLellan MD, Leiserson MD, Wendl MC, Zhang Q, Koboldt DC, Xie M, Kandoth C, McMichael JF, Wyczalkowski MA, Larson DE, Schmidt HK, Miller CA, Fulton RS, Spellman PT, Mardis ER, Druley TE, Graubert TA, Goodfellow PJ, Raphael BJ, Wilson RK, Ding LIntegrated analysis of germline and somatic variants in ovarian cancer.Nat Commun 5 3156 1/1/2014
  • Hsu YT, Gu F, Huang YW, Liu J, Ruan J, Huang RL, Wang CM, Chen CL, Jadhav RR, Lai HC, Mutch DG, Goodfellow PJ, Thompson IM, Kirma NB, Huang THPromoter hypomethylation of EpCAM-regulated bone morphogenetic protein gene family in recurrent endometrial cancer.Clin Cancer Res 19 6272-85 11/15/2013
  • Creutzberg CL, Kitchener HC, Birrer MJ, Landoni F, Lu KH, Powell M, Aghajanian C, Edmondson R, Goodfellow PJ, Quinn M, Salvesen HB, Thomas G, GCIG Endometrial Cancer Clinical Trials Planning MeetingGynecologic Cancer InterGroup (GCIG) endometrial cancer clinical trials planning meeting: taking endometrial cancer trials into the translational era.Int J Gynecol Cancer 23 1528-34 10/1/2013
  • Mach CM, Kim J, Soibam B, Creighton CJ, Hawkins SM, Zighelboim I, Goodfellow P, Gunaratne PH, Odunsi K, Salem PA, Anderson MLNovel MicroRNAs regulating proliferation and apoptosis in uterine papillary serous carcinomas.Cancer Lett 335 314-22 7/28/2013
  • Novetsky AP, Zighelboim I, Thompson DM Jr, Powell MA, Mutch DG, Goodfellow PJFrequent mutations in the RPL22 gene and its clinical and functional implications.Gynecol Oncol 128 470-4 3/1/2013
  • Roa JC, Goodfellow PJ, Kizer EL, Huang TH, Chen Y, Gu F, Doderer MS, Huang YWCMS: a web-based system for visualization and analysis of genome-wide methylation data of human cancers.PLoS One 8 e60980 1/1/2013
  • Yin Y, Kizer NT, Thaker PH, Chiappinelli KB, Trinkaus KM, Goodfellow PJ, Ma LGlycogen synthase kinase 3β inhibition as a therapeutic approach in the treatment of endometrial cancer.Int J Mol Sci 14 16617-37 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu