Nicholas Denko MD, PhD


Nicholas Denko MD, PhD
Assoc ProfessorCollege of Medicinedenko.2@osu.edu
524 Tzagournis Mes Res Facility 420 W 12th Avenue Columbus Ohio 43210
Phone:614-685-5843Fax:
  • Molecular Biology and Cancer Genetics

Research Description

Dr. Denko’s research is in the study of physiology that is unique to the solid tumor. This includes gene expression changes due to oxygen deprivation (hypoxia) and nutrient stress, and the resultant changes in tumor metabolism and response to conventional therapies.

Current Publications

  • Denko NCHypoxic regulation of metabolism offers new opportunities for anticancer therapy.Expert Rev Anticancer Ther in press 1-3 6/14/2014
  • Sun RC, Denko NCHypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth.Cell Metab 19 285-92 2/4/2014
  • Papandreou I, Liu B, Liu B, Pysz MA, Willmann JK, Knoefel WT, Denko NC, Sylvester KG, Lehwald N, Tao GZ, Jang KYβ-Catenin regulates hepatic mitochondrial function and energy balance in mice.Gastroenterology 143 754-64 9/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu