Thomas Ludwig PhD


Thomas Ludwig PhD
Assoc ProfessorCollege of MedicineThomas.Ludwig@osumc.eduwebsite
596 BRT 460 W 12th Avenue Columbus OH 43210
Phone:614-685-5679Fax:
  • Molecular Biology and Cancer Genetics

General Research Interest

Biological function(s) of BRCA1 and BRCA2 and some of their interacting partners in normal and malignant development.

Research Description

Dr. Ludwig's research focuses on biological function(s) of BRCA1 and BRCA2 and some of their interacting partners in normal and malignant development.

Current Publications

  • Simhadri S, Peterson S, Patel D, Huo Y, Cai H, Bowman-Colin C, Miller S, Ludwig T, Ganesan S, Bhaumik M, Bunting S, Jasin M, Xia BMale fertility defect associated with disrupted BRCA1-PALB2 interaction in mice.J Biol Chem in press 7/11/2014
  • Gupta A, Hunt CR, Hegde ML, Chakraborty S, Udayakumar D, Horikoshi N, Singh M, Ramnarain DB, Hittelman WN, Namjoshi S, Asaithamby A, Hazra TK, Ludwig T, Pandita RK, Tyler JK, Pandita TKMOF Phosphorylation by ATM Regulates 53BP1-Mediated Double-Strand Break Repair Pathway Choice.Cell Rep 8 177-89 7/10/2014
  • Polato F, Callen E, Wong N, Faryabi R, Bunting S, Chen HT, Kozak M, Kruhlak MJ, Reczek CR, Lee WH, Ludwig T, Baer R, Feigenbaum L, Jackson S, Nussenzweig ACtIP-mediated resection is essential for viability and can operate independently of BRCA1.J Exp Med 211 1027-36 6/2/2014
  • Tian F, Sharma S, Zou J, Lin SY, Wang B, Rezvani K, Wang H, Parvin JD, Ludwig T, Canman CE, Zhang DBRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade.Proc Natl Acad Sci U S A 110 13558-63 8/13/2013
  • Lucas AL, Shakya R, Lipsyc MD, Mitchel EB, Kumar S, Hwang C, Deng L, Devoe C, Chabot JA, Szabolcs M, Ludwig T, Chung WK, Frucht HHigh prevalence of BRCA1 and BRCA2 germline mutations with loss of heterozygosity in a series of resected pancreatic adenocarcinoma and other neoplastic lesions.Clin Cancer Res 19 3396-403 7/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu