Fen Xia MD, PhD


Fen Xia MD, PhD
ProfessorCollege of Medicinexia.153@osu.edu
Tzagournis Med Res Facility 420 W 12th Avenue Columbus Ohio 43210
Phone:614-293-8415Fax:
  • Molecular Biology and Cancer Genetics

General Research Interest

Breast and pancreatic cancer, malignant Brain tumor, molecular and cellular biology

Research Description

Research in the Xia laboratory focuses on elucidating the mechanisms that regulate the repair of chromosomal double-strand breaks (DSB) that arise during physiological DNA metabolism and after radiation therapy or chemotherapy. We aim to understand 1) the impact of deregulated DSB repair on carcinogenesis and the development of tumor resistance to therapy and 2) to explore novel avenues of cancer treatment targeting the DSB repair pathways. We have developed an array of intrachromosomal and extrachromosomal repair substrates that allow analysis of the quantity and quality of DSB repair by different mechanisms in mammalian cells. An understanding of the defects of DNA repair and its interplay with cell death within tumors; as well as the crosstalk between tumor cell DNA replication/repair process with its microenvironment may offer novel avenues for both cancer prevention and tailored therapy.

Current Publications

  • Santivasi WL, Xia FIonizing radiation-induced DNA damage, response, and repair.Antioxid Redox Signal 21 251-9 7/10/2014
  • Liebner DA, Walston SA, Cavaliere R, Powers CJ, Sauvageau E, Lehman NL, Wayne Slone H, Xu-Welliver M, Xia F, Kendra KLRadiation necrosis mimicking rapid intracranial progression of melanoma metastasis in two patients treated with vemurafenib.Melanoma Res 24 172-6 4/1/2014
  • Wang T, Wentz SC, Ausborn NL, Washington MK, Merchant N, Zhao Z, Shyr Y, Chakravarthy AB, Xia FPattern of breast cancer susceptibility gene 1 expression is a potential prognostic biomarker in resectable pancreatic ductal adenocarcinoma.Pancreas 42 977-82 8/1/2013
  • Fang M, Xia F, Mahalingam M, Virbasius CM, Wajapeyee N, Green MRMEN1 is a melanoma tumor suppressor that preserves genomic integrity by stimulating transcription of genes that promote homologous recombination-directed DNA repair.Mol Cell Biol 33 2635-47 7/1/2013
  • Willers H, Azzoli CG, Santivasi WL, Xia FBasic mechanisms of therapeutic resistance to radiation and chemotherapy in lung cancer.Cancer J 19 200-7 5/1/2013
  • Jiang G, Plo I, Wang T, Rahman M, Cho JH, Yang E, Lopez BS, Xia FBRCA1-Ku80 protein interaction enhances end-joining fidelity of chromosomal double-strand breaks in the G1 phase of the cell cycle.J Biol Chem 288 8966-76 3/29/2013
  • Santivasi WL, Xia FThe role and clinical significance of DNA damage response and repair pathways in primary brain tumors.Cell Biosci 3 10 1/1/2013
  • Ausborn NL, Wang T, Wentz SC, Washington MK, Merchant NB, Zhao Z, Shyr Y, Chakravarthy AB, Xia F53BP1 expression is a modifier of the prognostic value of lymph node ratio and CA 19-9 in pancreatic adenocarcinoma.BMC Cancer 13 155 1/1/2013
  • Yang ES, Nowsheen S, Rahman MA, Cook RS, Xia FTargeting BRCA1 localization to augment breast tumor sensitivity to poly(ADP-Ribose) polymerase inhibition.Cancer Res 72 5547-55 11/1/2012
  • Wentz SC, Zhao ZG, Shyr Y, Shi CJ, Merchant NB, Washington K, Xia F, Chakravarthy ABLymph node ratio and preoperative CA 19-9 levels predict overall survival and recurrence-free survival in patients with resected pancreatic adenocarcinoma.World J Gastrointest Oncol 4 207-15 10/15/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu