Katsumi Kitagawa PhD

Katsumi Kitagawa PhD
Assoc ProfessorCollege of MedicineKatsumi.Kitagawa@nationwidechildrens.org
WA5014 Center for Childhood Cancer 700 Children's Drive Columbus OH 43205
Phone:(614) 355-2632Fax: (614) 722-5895
  • Molecular Biology and Cancer Genetics

Research Description

Dr. Kitagawa's research involves the role that the spindle checkpoint plays in tumor development. Mutations in genes required for kinetochore function and mitotic checkpoint surveillance possibly contribute development of cancer. His lab is employing a series of genetic and biochemical strategies to identify additional interacting gene products, regulators, and potential substrates of Sgt1/Skp1/Hsp90 action in yeast and vertebrates. In studies with human cells, they have found a novel mechanism by which 17-AAG (an Hsp90 inhibitor and a novel anti-cancer drug) inhibits cell proliferation and provide the first evidence of HSP90 being required for assembly of kinetochore protein complexes in humans.

Current Publications

  • Ohkuni K, Abdulle R, Kitagawa KDegradation of centromeric histone H3 variant Cse4 requires the Fpr3 peptidyl-prolyl Cis-Trans isomerase.Genetics 196 1041-5 4/1/2014
  • Bian Y, Kitagawa R, Bansal PK, Fujii Y, Stepanov A, Kitagawa KSynthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors.Proc Natl Acad Sci U S A 111 1628-33 1/28/2014

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu