General Research InterestRoles of cytoskeletal and signaling proteins in cellular asymmetry and cell division in normal, cancer, and stem cells.
Research DescriptionThe long-term goal of our laboratory is to understand the roles of cytoskeletal and signaling proteins in cellular asymmetry and cell division in normal and cancer cells. In the near term, we are focusing on the molecular mechanisms of cytokinesis in the fission yeast S. pombe. Cytokinesis partitions cellular constituents into two daughter cells at the end of the cell cycle. When coordinated with the generation of cellular asymmetry, cytokinesis can produce diverse cell types in multicellular organisms. Thus, cytokinesis plays a crucial role in both cell proliferation and cell differentiation.