Chang-hyuk Kwon PhD


Chang-hyuk Kwon PhD
Asst ProfessorCollege of Medicinekwon.172@osu.edu
820 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-688-5867Fax:
  • Molecular Biology and Cancer Genetics

General Research Interest

Mouse models of glioblastoma, cancer stem cells, identification of tumor driver, cellular origin of glioma, PTEN signaling in the brain 

Research Description

Dr. Kwon's laboratory is studying glioblastoma, the most aggressive and common brain malignancy with poor prognosis. By using Nf1, Trp53 and Pten conditional deletion in the brain, we have generated physiologically relevant mouse genetic models of this devastating disease. We also have demonstrated that a majority of the brain tumor type originates from neural stem cell lineage. By culturing the origin and tumor cells in neurosphere and monitoring molecular and cellular changes during the tumor development, we are searching for tumor drivers responsible for glioblastoma formation. 

Current Publications

  • Kim SH, Kwon CH, Nakano IDetoxification of oxidative stress in glioma stem cells: Mechanism, clinical relevance, and therapeutic development.J Neurosci Res 92 1419-24 11/1/2014
  • Kim TH, Song J, Kim SH, Parikh AK, Mo X, Palanichamy K, Kaur B, Yu J, Yoon SO, Nakano I, Kwon CHPiperlongumine treatment inactivates peroxiredoxin 4, exacerbates endoplasmic reticulum stress, and preferentially kills high-grade glioma cells.Neuro Oncol 16 1354-64 10/1/2014
  • Chu J, He S, Deng Y, Zhang J, Peng Y, Hughes T, Yi L, Kwon CH, Wang QE, Devine SM, He X, Bai XF, Hofmeister CC, Yu JGenetic modification of T cells redirected toward CS1 enhances eradication of myeloma cells.Clin Cancer Res 20 3989-4000 8/1/2014
  • Wojton J, Meisen WH, Jacob NK, Thorne AH, Hardcastle J, Denton N, Chu Z, Dmitrieva N, Marsh R, Van Meir EG, Kwon CH, Chakravarti A, Qi X, Kaur BSapC-DOPS-induced lysosomal cell death synergizes with TMZ in glioblastoma.Oncotarget in press 7/17/2014
  • Chiocca E Antonio, Price RL, Hollon T, Alvarez-Breackenridge C, Fernandez S, Oglesbee Mike, Cook C, Lawler S, Kwon Chang-HyukCytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.Neuro Oncol 16 Suppl 3 iii8 7/1/2014
  • Martin LK, Cordero-Nieves HM, Banasavadi-Siddegowda Y, Virk S, Barnholtz-Sloan J, Bell EH, Wojton J, Jacob NK, Chakravarti A, Nowicki MO, Wu X, Lapalombella R, Datta J, Yu B, Gordon K, Haseley A, Patton JT, Smith PL, Ryu J, Zhang X, Yan F, Alinari L, Lustberg ME, Mo X, Marcucci G, Nuovo G, Kwon CH, Byrd JC, Chiocca EA, Li C, Sif S, Jacob S, Lawler S, Kaur B, Baiocchi RAGenetic validation of the protein arginine methyltransferase PRMT5 as a candidate therapeutic target in glioblastoma.Cancer Res 74 1752-65 3/15/2014
  • Hollon TC, Price RL, Kwon CH, Chiocca EAMutations in glioblastoma oncosuppressive pathways pave the way for oncomodulatory activity of cytomegalovirus.Oncoimmunology 2 e25620 9/1/2013
  • Peruzzi P, Bronisz A, Nowicki MO, Wang Y, Ogawa D, Price R, Nakano I, Kwon CH, Hayes J, Lawler SE, Ostrowski MC, Chiocca EA, Godlewski JMicroRNA-128 coordinately targets Polycomb Repressor Complexes in glioma stem cells.Neuro Oncol 15 1212-24 9/1/2013
  • Wojton J, Chu Z, Mathsyaraja H, Meisen WH, Denton N, Kwon CH, Chow LM, Palascak M, Franco R, Bourdeau T, Thornton S, Ostrowski MC, Kaur B, Qi XSystemic delivery of SapC-DOPS has antiangiogenic and antitumor effects against glioblastoma.Mol Ther 21 1517-25 8/1/2013
  • Price RL, Song J, Bingmer K, Kim TH, Yi JY, Nowicki MO, Mo X, Hollon T, Kwon CH, Murnan E, Alvarez-Breckenridge C, Fernandez S, Kaur B, Rivera A, Oglesbee M, Cook C, Chiocca EACytomegalovirus contributes to glioblastoma in the context of tumor suppressor mutations.Cancer Res 73 3441-50 6/1/2013
  • Guvenc H, Pavlyukov MS, Joshi K, Kurt H, Banasavadi-Siddegowda YK, Mao P, Hong C, Yamada R, Kwon CH, Bhasin D, Chettiar S, Kitange G, Park IH, Sarkaria JN, Li C, Shakhparonov MI, Nakano IImpairment of glioma stem cell survival and growth by a novel inhibitor for Survivin-Ran protein complex.Clin Cancer Res 19 631-42 2/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu