Jeffrey Parvin MD, PhD


Jeffrey Parvin MD, PhD
ProfessorCollege of Medicineparvin.4@osu.edu
3190 Graves Hall 333 W 10th Avenue Columbus Ohio 43210
Phone:614-292-0523Fax:
  • Molecular Biology and Cancer Genetics

General Research Interest

breast cancer, systems biology, molecular biology

Research Description

Dr. Parvin's research involves the biological processes involved in breast cancer.  His lab focuses on pathways regulated by the BRCA1 and BRCA2 tumor suppressor proteins, and these include the repair of DNA damage, control of transcription, control of cell cycle progression, and centrosome control.  Dr. Parvin uses a variety of methods that include the use of informatics to generate hypotheses and biochemical and molecular biology experiments using tissue culture models.

Transinstitutional Work

As Director of the Biomedical Shared Resource, Dr. Parvin collaborates with a number of OSU labs in the analysis of data-intensive experiments, such as gene expression analysis and next-generation sequence analysis.  The Parvin laboratory collaborates with the Huang and Catalyurek groups to develop new informatics methods for deriving biologically useful hypotheses that can be tested in the laboratory.  The laboratory collaborates with breast cancer physicians in order to develop new antibody-based biomarker methods for the evaluation of breast cancer cases.  The Parvin laboratory is also in the Tumor Microenvironment program.

Current Publications

  • Kotian S, Banerjee T, Lockhart A, Huang K, Catalyurek UV, Parvin JDNUSAP1 influences the DNA damage response by controlling BRCA1 protein levels.Cancer Biol Ther 15 533-43 5/1/2014
  • Liebner DA, Huang K, Parvin JDMMAD: microarray microdissection with analysis of differences is a computational tool for deconvoluting cell type-specific contributions from tissue samples.Bioinformatics 30 682-9 3/1/2014
  • Hu Y, Wang C, Huang K, Xia F, Parvin JD, Mondal NRegulation of 53BP1 Protein Stability by RNF8 and RNF168 Is Important for Efficient DNA Double-Strand Break Repair.PLoS One 9 e110522 1/1/2014
  • Acharya S, Kaul Z, Gocha AS, Martinez AR, Harris J, Parvin JD, Groden JAssociation of BLM and BRCA1 during Telomere Maintenance in ALT Cells.PLoS One 9 e103819 1/1/2014
  • Tian F, Sharma S, Zou J, Lin SY, Wang B, Rezvani K, Wang H, Parvin JD, Ludwig T, Canman CE, Zhang DBRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade.Proc Natl Acad Sci U S A 110 13558-63 8/13/2013
  • Webb A, Papp AC, Sanford JC, Huang K, Parvin JD, Sadee WExpression of mRNA transcripts encoding membrane transporters detected with whole transcriptome sequencing of human brain and liver.Pharmacogenet Genomics 23 269-78 5/1/2013
  • Towler WI, Zhang J, Ransburgh DJ, Toland AE, Ishioka C, Chiba N, Parvin JDAnalysis of BRCA1 variants in double-strand break repair by homologous recombination and single-strand annealing.Hum Mutat 34 439-45 3/1/2013
  • Zhang J, Ni S, Xiang Y, Parvin JD, Yang Y, Zhou Y, Huang KGene Co-expression analysis predicts genetic aberration loci associated with colon cancer metastasis.Int J Comput Biol Drug Des 6 60-71 1/1/2013
  • Wang J, Lan X, Hsu PY, Hsu HK, Huang K, Parvin J, Huang TH, Jin VXGenome-wide analysis uncovers high frequency, strong differential chromosomal interactions and their associated epigenetic patterns in E2-mediated gene regulation.BMC Genomics 14 70 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu