P Mark Bloomston MD


P Mark Bloomston MD
Assoc ProfessorCollege of Medicinebloomston.1@osu.edu
N924 Doan Hall 410 W 10th Avenue Columbus Ohio 43210
Phone:614-293-4583Fax: (614) 293-3465
  • Translational Therapeutics

General Research Interest

Clinical interests deal with the management of cancers of the liver, biliary tree, and pancreas as well as neuroendocrine cancers. Research in these areas include clinical trials, outcomes analysis, and molecular correlative studies. Basic science research focuses on the role of microRNAs in pancreatic cancer.

Research Description

My lab focuses on the mechanisms by which microRNAs are induced and function in pancreatic cancer. Specifically, we have an interest in how cellular stressors in the pancreatic cancer microenvironment result in the induction or repression of microRNAs, thus providing the pancreatic cancer cell a selective advantage. We also look at how cancer and non-cancer cells use microRNAs to communicate within the pancreatic tumor. Other collaborative studies investigate the use of microRNAs for early detection of premalignant and malignant lesions of the pancreas.

Transinstitutional Work

Our lab collaborates with other pancreatic cancer researchers on and off of the OSU campus. These include researchers in the College of Pharmacy and Department of Medicine at OSU, Nationwide Children's Hospital, Massachusetts General Hospital, and the University of Verona, Italy.

Current Publications

  • Schmidt C, Rilling WS, Gamblin TC, Martin RC, North DA, Groeschl RT, Sindram D, Martinie JB, Iannitti DA, Bloomston MMicrowave ablation for hepatic malignancies: a call for standard reporting and outcomes.Am J Surg 208 284-294 8/1/2014
  • Kooby DA, Maithel SK, Li A, Wu MC, Sarmiento JM, Bloomston M, Christians KK, Johnston FM, Tsai S, Turaga KK, Tsung A, Pawlik TM, Gamblin TC, Miura JT, Amini A, Schmocker R, Nichols S, Sukato D, Winslow ER, Spolverato G, Ejaz A, Squires MHSurgical management of hepatic hemangiomas: a multi-institutional experience.HPB (Oxford) in press 6/19/2014
  • Spolverato G, Kim Y, Ejaz A, Valero V, Squires MH, Poultsides G, Fields RC, Bloomston M, Weber SM, Acher AW, Votanopoulos K, Schmidt C, Cho CS, Maithel SK, Pawlik TMA Multi-institutional Analysis of Open Versus Minimally-Invasive Surgery for Gastric Adenocarcinoma: Results of the US Gastric Cancer Collaborative.J Gastrointest Surg in press 6/10/2014
  • Groeschl RT, Pilgrim CH, Hanna EM, Simo KA, Swan RZ, Sindram D, Martinie JB, Iannitti DA, Bloomston M, Schmidt C, Khabiri H, Shirley LA, Martin RC, Tsai S, Turaga KK, Christians KK, Rilling WS, Gamblin TCMicrowave ablation for hepatic malignancies: a multiinstitutional analysis.Ann Surg 259 1195-200 6/1/2014
  • Lai IL, Chou CC, Lai PT, Fang CS, Shirley LA, Yan R, Mo X, Bloomston M, Kulp SK, Bekaii-Saab T, Chen CSTargeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells.Carcinogenesis in press 5/30/2014
  • Groeschl RT, Miura JT, Wong RK, Bloomston M, Lidsky ML, Clary BM, Martin RC, Belli G, Buell JF, Gamblin TCMulti-institutional analysis of recurrence and survival after hepatectomy for fibrolamellar carcinoma.J Surg Oncol in press 5/21/2014
  • Ejaz A, Spolverato G, Kim Y, Squires MH, Poultsides G, Fields R, Bloomston M, Weber SM, Votanopoulos K, Worhunsky DJ, Swords D, Jin LX, Schmidt C, Acher AW, Saunders N, Cho CS, Herman JM, Maithel SK, Pawlik TMImpact of External-Beam Radiation Therapy on Outcomes Among Patients with Resected Gastric Cancer: A Multi-institutional Analysis.Ann Surg Oncol in press 5/21/2014
  • Van Buren G, Bloomston M, Hughes SJ, Winter J, Behrman SW, Zyromski NJ, Vollmer C, Velanovich V, Riall T, Muscarella P, Trevino J, Nakeeb A, Schmidt CM, Behrns K, Ellison EC, Barakat O, Perry KA, Drebin J, House M, Abdel-Misih S, Silberfein EJ, Goldin S, Brown K, Mohammed S, Hodges SE, McElhany A, Issazadeh M, Jo E, Mo Q, Fisher WEA randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage.Ann Surg 259 605-12 4/1/2014
  • Keplinger KM, Bloomston MAnatomy and embryology of the biliary tract.Surg Clin North Am 94 203-17 4/1/2014
  • Luu DC, Li X, Muscarella P, Ellison EC, Bloomston M, Bekaii-Saab T, Martin LKThe addition of radiation to chemotherapy does not improve outcome when compared to chemotherapy in the treatment of resected pancreas cancer: the results of a single-institution experience.Ann Surg Oncol 21 862-7 3/1/2014
  • Collins A, Hatzaras I, Schmidt C, Carruthers K, Melvin WS, Muscarella P, Ellison EC, Martin E, Bloomston MGastrectomy in advanced gastric cancer effectively palliates symptoms and may improve survival in select patients.J Gastrointest Surg 18 491-6 3/1/2014
  • Sandroussi C, Marsh W, Pawlik TM, Arnaoutakis DJ, Kim Y, Pulitano C, Zaydfudim V, Squires MH, Kooby D, Groeschl R, Alexandrescu S, Bauer TW, Bloomston M, Soares K, Marques H, Gamblin TC, Popescu I, Adams R, Nagorney D, Barroso E, Maithel SK, Crawford MManagement of Biliary Cystic Tumors: A Multi-institutional Analysis of a Rare Liver Tumor.Ann Surg in press 2/6/2014
  • Collins AL, Wojcik S, Liu J, Frankel WL, Alder H, Yu L, Schmittgen TD, Croce CM, Bloomston MA differential microRNA profile distinguishes cholangiocarcinoma from pancreatic adenocarcinoma.Ann Surg Oncol 21 133-8 1/1/2014
  • Bloomston MReadmissions following pancreatoduodenectomy: it's when things don't go well that experienced pancreatic surgeons earn their keep.JAMA Surg 148 1102 12/1/2013
  • Bloomston M, Henry JC, Bassi C, Giovinazzo FMicroRNA from pancreatic duct aspirate differentiates cystic lesions of the pancreas.Ann Surg Oncol 20 Suppl 3 S661-6 12/1/2013
  • Cardillo VM, Acharyya S, Aulino P, Thomas-Ahner J, Wang J, Bloomston M, Muscarella P, Nau P, Shah N, Butchbach ME, Ladner K, Adamo S, He WA, Berardi E, Rudnicki MA, Keller C, Coletti D, Montanaro F, Guttridge DCNF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia.J Clin Invest 123 4821-35 11/1/2013
  • Mace TA, Collins AL, Wojcik SE, Croce CM, Lesinski GB, Bloomston MHypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells.J Surg Res 184 855-60 10/1/2013
  • Kim EJ, Ben-Josef E, Herman JM, Bekaii-Saab T, Dawson LA, Griffith KA, Francis IR, Greenson JK, Simeone DM, Lawrence TS, Laheru D, Wolfgang CL, Williams T, Bloomston M, Moore MJ, Wei A, Zalupski MMA multi-institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer.Cancer 119 2692-700 8/1/2013
  • Mace TA, Bloomston M, Lesinski GBPancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment.Oncoimmunology 2 e24891 7/1/2013
  • Haraldsdottir S, Wu C, Bloomston M, Goldberg RMWhat is the optimal neo-adjuvant treatment for liver metastasis?Ther Adv Med Oncol 5 221-34 7/1/2013
  • Mace TA, Ameen Z, Collins A, Wojcik S, Mair M, Young GS, Fuchs JR, Eubank TD, Frankel WL, Bekaii-Saab T, Bloomston M, Lesinski GBPancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner.Cancer Res 73 3007-18 5/15/2013
  • Schmittgen T, Bloomston M, McNally ME, Collins A, Wojcik SE, Liu J, Henry JC, Jiang JConcomitant dysregulation of microRNAs miR-151-3p and miR-126 correlates with improved survival in resected cholangiocarcinoma.HPB (Oxford) 15 260-4 4/1/2013
  • Arrese D, McNally ME, Chokshi R, Feria-Arias E, Schmidt C, Klemanski D, Gregory G, Khabiri H, Shah M, Bloomston MExtrahepatic disease should not preclude transarterial chemoembolization for metastatic neuroendocrine carcinoma.Ann Surg Oncol 20 1114-20 4/1/2013
  • Heo J, Reid T, Ruo L, Breitbach CJ, Rose S, Bloomston M, Cho M, Lim HY, Chung HC, Kim CW, Burke J, Lencioni R, Hickman T, Moon A, Lee YS, Kim MK, Daneshmand M, Dubois K, Longpre L, Ngo M, Rooney C, Bell JC, Rhee BG, Patt R, Hwang TH, Kirn DHRandomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer.Nat Med 19 329-36 3/1/2013
  • McNally ME, Martinez A, Khabiri H, Guy G, Michaels AJ, Hanje J, Kirkpatrick R, Bloomston M, Schmidt CRInflammatory markers are associated with outcome in patients with unresectable hepatocellular carcinoma undergoing transarterial chemoembolization.Ann Surg Oncol 20 923-8 3/1/2013
  • Henry JC, Malhotra L, Khabiri H, Guy G, Michaels A, Hanje J, Azevedo M, Bloomston M, Schmidt CRBest radiological response to trans-arterial chemoembolization for hepatocellular carcinoma does not imply better outcomes.HPB (Oxford) 15 196-202 3/1/2013
  • Shirley LA, Aguilar LK, Aguilar-Cordova E, Bloomston M, Walker JPTherapeutic endoscopic ultrasonography: intratumoral injection for pancreatic adenocarcinoma.Gastroenterol Res Pract 2013 207129 1/1/2013
  • Huntington JT, Butterfield M, Fisher J, Torrent D, Bloomston MThe Social Security Death Index (SSDI) most accurately reflects true survival for older oncology patients.Am J Cancer Res 3 518-22 1/1/2013
  • Jones NB, Wakely PE, Klemanski DL, Al-Saif O, Young G, Frankel WL, Martin EW, Bloomston MCytopathologic evaluation of the in situ margin in patients undergoing hepatectomy.Cancer Cytopathol 120 410-5 12/25/2012
  • Martin LK, Grecula J, Jia G, Wei L, Yang X, Otterson GA, Wu X, Harper E, Kefauver C, Zhou BS, Yen Y, Bloomston M, Knopp M, Ivy SP, Grever M, Bekaii-Saab TA dose escalation and pharmacodynamic study of triapine and radiation in patients with locally advanced pancreas cancer.Int J Radiat Oncol Biol Phys 84 e475-81 11/15/2012
  • Martin LK, Li X, Kleiber B, Ellison EC, Bloomston M, Zalupski M, Bekaii-Saab TSVEGF remains an interesting target in advanced pancreas cancer (APCA): results of a multi-institutional phase II study of bevacizumab, gemcitabine, and infusional 5-fluorouracil in patients with APCA.Ann Oncol 23 2812-20 11/1/2012
  • Henry JC, Pouly S, Sullivan R, Sharif S, Klemanski D, Abdel-Misih S, Arradaza N, Jarjoura D, Schmidt C, Bloomston MA scoring system for the prognosis and treatment of malignant bowel obstruction.Surgery 152 747-56; discussion 756-7 10/1/2012
  • Martin LK, Cucci A, Wei L, Rose J, Blazer M, Schmidt C, Khabiri H, Bloomston M, Bekaii-Saab TYttrium-90 radioembolization as salvage therapy for colorectal cancer with liver metastases.Clin Colorectal Cancer 11 195-9 9/1/2012
  • Aldrighetti L, Choti M, Shen F, Kamel I, Geschwind JF, Pawlik TM, Peng PD, Hyder O, Bloomston M, Marques H, Corona-Villalobos C, Dixon E, Pulitano C, Hirose K, Schulick RD, Barroso ESequential intra-arterial therapy and portal vein embolization is feasible and safe in patients with advanced hepatic malignancies.HPB (Oxford) 14 523-31 8/1/2012
  • Collins AL, Rock J, Malhotra L, Frankel WL, Bloomston MOsteopontin expression is associated with improved survival in patients with pancreatic adenocarcinoma.Ann Surg Oncol 19 2673-8 8/1/2012
  • Fisher SB, Patel SH, Kooby DA, Weber S, Bloomston M, Cho C, Hatzaras I, Schmidt C, Winslow E, Staley CA, Maithel SKLymphovascular and perineural invasion as selection criteria for adjuvant therapy in intrahepatic cholangiocarcinoma: a multi-institution analysis.HPB (Oxford) 14 514-22 8/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu