P Mark Bloomston MD


P Mark Bloomston MD
Assoc ProfessorCollege of Medicinebloomston.1@osu.edu
N924 Doan Hall 410 W 10th Avenue Columbus Ohio 43210
Phone:614-293-4583Fax: (614) 293-3465
  • Translational Therapeutics

General Research Interest

Clinical interests deal with the management of cancers of the liver, biliary tree, and pancreas as well as neuroendocrine cancers. Research in these areas include clinical trials, outcomes analysis, and molecular correlative studies. Basic science research focuses on the role of microRNAs in pancreatic cancer.

Research Description

My lab focuses on the mechanisms by which microRNAs are induced and function in pancreatic cancer. Specifically, we have an interest in how cellular stressors in the pancreatic cancer microenvironment result in the induction or repression of microRNAs, thus providing the pancreatic cancer cell a selective advantage. We also look at how cancer and non-cancer cells use microRNAs to communicate within the pancreatic tumor. Other collaborative studies investigate the use of microRNAs for early detection of premalignant and malignant lesions of the pancreas.

Transinstitutional Work

Our lab collaborates with other pancreatic cancer researchers on and off of the OSU campus. These include researchers in the College of Pharmacy and Department of Medicine at OSU, Nationwide Children's Hospital, Massachusetts General Hospital, and the University of Verona, Italy.

Current Publications

  • Blazer M, Wu C, Goldberg RM, Phillips G, Schmidt C, Muscarella P, Wuthrick E, Williams TM, Reardon J, Christopher Ellison E, Bloomston M, Bekaii-Saab TNeoadjuvant Modified (m) FOLFIRINOX for Locally Advanced Unresectable (LAPC) and Borderline Resectable (BRPC) Adenocarcinoma of the Pancreas.Ann Surg Oncol in press 10/31/2014
  • Nichols SD, Albert S, Shirley L, Schmidt C, Abdel-Misih S, El-Dika S, Groce JR, Wu C, Goldberg RM, Bekaii-Saab T, Bloomston MOutcomes in Patients with Obstructive Jaundice from Metastatic Colorectal Cancer and Implications for Management.J Gastrointest Surg in press 10/10/2014
  • Kim Y, Ejaz A, Spolverato G, Squires MH, Poultsides G, Fields RC, Bloomston M, Weber SM, Votanopoulos K, Acher AW, Jin LX, Hawkins WG, Schmidt C, Kooby D, Worhunsky D, Saunders N, Cho CS, Levine EA, Maithel SK, Pawlik TMConditional Survival after Surgical Resection of Gastric Cancer: A Multi-Institutional Analysis of the US Gastric Cancer Collaborative.Ann Surg Oncol in press 10/7/2014
  • Ejaz A, Spolverato G, Kim Y, Squires MH, Poultsides G, Fields R, Bloomston M, Weber SM, Swords D, Jin LX, Schmidt C, Acher AW, Saunders N, Cho CS, Herman JM, Maithel SK, Pawlik TM, Votanopoulos K, Worhunsky DJImpact of External-Beam Radiation Therapy on Outcomes Among Patients with Resected Gastric Cancer: A Multi-institutional Analysis.Ann Surg Oncol 21 3412-21 10/1/2014
  • Miura JT, Amini A, Schmocker R, Nichols S, Sukato D, Winslow ER, Spolverato G, Ejaz A, Squires MH, Kooby DA, Maithel SK, Li A, Wu MC, Sarmiento JM, Bloomston M, Christians KK, Johnston FM, Tsai S, Turaga KK, Tsung A, Pawlik TM, Gamblin TCSurgical management of hepatic hemangiomas: a multi-institutional experience.HPB (Oxford) 16 924-8 10/1/2014
  • Groeschl RT, Miura JT, Wong RK, Bloomston M, Lidsky ML, Clary BM, Martin RC, Belli G, Buell JF, Gamblin TCMulti-institutional analysis of recurrence and survival after hepatectomy for fibrolamellar carcinoma.J Surg Oncol 110 412-5 9/1/2014
  • Schmidt C, Cho CS, Maithel SK, Pawlik TM, Spolverato G, Kim Y, Ejaz A, Valero V 3rd, Squires MH, Poultsides G, Fields RC, Bloomston M, Weber SM, Acher AW, Votanopoulos KA Multi-institutional Analysis of Open Versus Minimally-Invasive Surgery for Gastric Adenocarcinoma: Results of the US Gastric Cancer Collaborative.J Gastrointest Surg 18 1563-74 9/1/2014
  • Beal EW, Albert S, McNally M, Shirley LA, Hanje J, Michaels AJ, Black SM, Bloomston M, Schmidt CRAn indeterminate nodule in the cirrhotic liver discovered by surveillance imaging is a prelude to malignancy.J Surg Oncol in press 8/25/2014
  • Benson AB 3rd, D'Angelica MI, Abrams TA, Are C, Bloomston PM, Chang DT, Clary BM, Covey AM, Ensminger WD, Iyer R, Kelley RK, Linehan D, Malafa MP, Meranze SG, Park JO, Pawlik T, Posey JA, Scaife C, Schefter T, Sigurdson ER, Tian GG, Vauthey JN, Venook AP, Yen Y, Zhu AX, Hoffmann KG, McMillian NR, Sundar HHepatobiliary cancers, version 2.2014.J Natl Compr Canc Netw 12 1152-82 8/1/2014
  • North DA, Groeschl RT, Sindram D, Martinie JB, Iannitti DA, Bloomston M, Schmidt C, Rilling WS, Gamblin TC, Martin RCMicrowave ablation for hepatic malignancies: a call for standard reporting and outcomes.Am J Surg 208 284-94 8/1/2014
  • Turaga KK, Christians KK, Rilling WS, Gamblin TC, Groeschl RT, Pilgrim CH, Hanna EM, Simo KA, Swan RZ, Sindram D, Martinie JB, Iannitti DA, Bloomston M, Schmidt C, Khabiri H, Shirley LA, Martin RC, Tsai SMicrowave ablation for hepatic malignancies: a multiinstitutional analysis.Ann Surg 259 1195-200 6/1/2014
  • Lai IL, Chou CC, Lai PT, Fang CS, Shirley LA, Yan R, Mo X, Bloomston M, Kulp SK, Bekaii-Saab T, Chen CSTargeting the Warburg effect with a novel glucose transporter inhibitor to overcome gemcitabine resistance in pancreatic cancer cells.Carcinogenesis in press 5/30/2014
  • Van Buren G 2nd, Bloomston M, Hughes SJ, Winter J, Behrman SW, Zyromski NJ, Vollmer C, Velanovich V, Riall T, Muscarella P, Trevino J, Nakeeb A, Schmidt CM, Behrns K, Ellison EC, Barakat O, Perry KA, Drebin J, House M, Abdel-Misih S, Silberfein EJ, Goldin S, Brown K, Mohammed S, Hodges SE, McElhany A, Issazadeh M, Jo E, Mo Q, Fisher WEA randomized prospective multicenter trial of pancreaticoduodenectomy with and without routine intraperitoneal drainage.Ann Surg 259 605-12 4/1/2014
  • Keplinger KM, Bloomston MAnatomy and embryology of the biliary tract.Surg Clin North Am 94 203-17 4/1/2014
  • Martin LK, Luu DC, Li X, Muscarella P, Ellison EC, Bloomston M, Bekaii-Saab TThe addition of radiation to chemotherapy does not improve outcome when compared to chemotherapy in the treatment of resected pancreas cancer: the results of a single-institution experience.Ann Surg Oncol 21 862-7 3/1/2014
  • Collins A, Hatzaras I, Schmidt C, Carruthers K, Melvin WS, Muscarella P, Ellison EC, Martin E, Bloomston MGastrectomy in advanced gastric cancer effectively palliates symptoms and may improve survival in select patients.J Gastrointest Surg 18 491-6 3/1/2014
  • Arnaoutakis DJ, Kim Y, Pulitano C, Zaydfudim V, Squires MH, Kooby D, Groeschl R, Alexandrescu S, Bauer TW, Bloomston M, Soares K, Marques H, Gamblin TC, Popescu I, Adams R, Nagorney D, Barroso E, Maithel SK, Crawford M, Sandroussi C, Marsh W, Pawlik TMManagement of Biliary Cystic Tumors: A Multi-institutional Analysis of a Rare Liver Tumor.Ann Surg in press 2/6/2014
  • Osayi SN, Bloomston M, Schmidt CM, Ellison EC, Muscarella PBiomarkers as Predictors of Recurrence following Curative Resection for Pancreatic Ductal Adenocarcinoma: A Review.Biomed Res Int 2014 468959 1/1/2014
  • Liu J, Frankel WL, Alder H, Yu L, Schmittgen TD, Croce CM, Bloomston M, Collins AL, Wojcik SA differential microRNA profile distinguishes cholangiocarcinoma from pancreatic adenocarcinoma.Ann Surg Oncol 21 133-8 1/1/2014
  • Bloomston MReadmissions following pancreatoduodenectomy: it's when things don't go well that experienced pancreatic surgeons earn their keep.JAMA Surg 148 1102 12/1/2013
  • Henry JC, Bassi C, Giovinazzo F, Bloomston MMicroRNA from pancreatic duct aspirate differentiates cystic lesions of the pancreas.Ann Surg Oncol 20 Suppl 3 S661-6 12/1/2013
  • He WA, Berardi E, Cardillo VM, Acharyya S, Aulino P, Thomas-Ahner J, Wang J, Bloomston M, Muscarella P, Nau P, Shah N, Butchbach ME, Ladner K, Adamo S, Rudnicki MA, Keller C, Coletti D, Montanaro F, Guttridge DCNF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia.J Clin Invest 123 4821-35 11/1/2013
  • Mace TA, Collins AL, Wojcik SE, Croce CM, Lesinski GB, Bloomston MHypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells.J Surg Res 184 855-60 10/1/2013
  • Griffith KA, Francis IR, Greenson JK, Simeone DM, Lawrence TS, Laheru D, Wolfgang CL, Williams T, Bloomston M, Moore MJ, Wei A, Zalupski MM, Kim EJ, Ben-Josef E, Herman JM, Bekaii-Saab T, Dawson LAA multi-institutional phase 2 study of neoadjuvant gemcitabine and oxaliplatin with radiation therapy in patients with pancreatic cancer.Cancer 119 2692-700 8/1/2013
  • Mace TA, Bloomston M, Lesinski GBPancreatic cancer-associated stellate cells: A viable target for reducing immunosuppression in the tumor microenvironment.Oncoimmunology 2 e24891 7/1/2013
  • Haraldsdottir S, Wu C, Bloomston M, Goldberg RMWhat is the optimal neo-adjuvant treatment for liver metastasis?Ther Adv Med Oncol 5 221-34 7/1/2013
  • Bloomston M, Lesinski GB, Mace TA, Ameen Z, Collins A, Wojcik S, Mair M, Young GS, Fuchs JR, Eubank TD, Frankel WL, Bekaii-Saab TPancreatic cancer-associated stellate cells promote differentiation of myeloid-derived suppressor cells in a STAT3-dependent manner.Cancer Res 73 3007-18 5/15/2013
  • McNally ME, Collins A, Wojcik SE, Liu J, Henry JC, Jiang J, Schmittgen T, Bloomston MConcomitant dysregulation of microRNAs miR-151-3p and miR-126 correlates with improved survival in resected cholangiocarcinoma.HPB (Oxford) 15 260-4 4/1/2013
  • Arrese D, McNally ME, Chokshi R, Feria-Arias E, Schmidt C, Klemanski D, Gregory G, Khabiri H, Shah M, Bloomston MExtrahepatic disease should not preclude transarterial chemoembolization for metastatic neuroendocrine carcinoma.Ann Surg Oncol 20 1114-20 4/1/2013
  • Heo J, Reid T, Ruo L, Breitbach CJ, Rose S, Bloomston M, Cho M, Lim HY, Chung HC, Kim CW, Burke J, Lencioni R, Hickman T, Moon A, Lee YS, Kim MK, Daneshmand M, Dubois K, Longpre L, Ngo M, Rooney C, Bell JC, Rhee BG, Patt R, Hwang TH, Kirn DHRandomized dose-finding clinical trial of oncolytic immunotherapeutic vaccinia JX-594 in liver cancer.Nat Med 19 329-36 3/1/2013
  • Azevedo M, Bloomston M, Schmidt CR, Henry JC, Malhotra L, Khabiri H, Guy G, Michaels A, Hanje JBest radiological response to trans-arterial chemoembolization for hepatocellular carcinoma does not imply better outcomes.HPB (Oxford) 15 196-202 3/1/2013
  • McNally ME, Martinez A, Khabiri H, Guy G, Michaels AJ, Hanje J, Kirkpatrick R, Bloomston M, Schmidt CRInflammatory markers are associated with outcome in patients with unresectable hepatocellular carcinoma undergoing transarterial chemoembolization.Ann Surg Oncol 20 923-8 3/1/2013
  • Shirley LA, Aguilar LK, Aguilar-Cordova E, Bloomston M, Walker JPTherapeutic endoscopic ultrasonography: intratumoral injection for pancreatic adenocarcinoma.Gastroenterol Res Pract 2013 207129 1/1/2013
  • Huntington JT, Butterfield M, Fisher J, Torrent D, Bloomston MThe Social Security Death Index (SSDI) most accurately reflects true survival for older oncology patients.Am J Cancer Res 3 518-22 1/1/2013
  • Jones NB, Wakely PE Jr, Klemanski DL, Al-Saif O, Young G, Frankel WL, Martin EW, Bloomston MCytopathologic evaluation of the in situ margin in patients undergoing hepatectomy.Cancer Cytopathol 120 410-5 12/25/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu