Denis C Guttridge PhD

Denis C Guttridge PhD
ProfessorCollege of
910 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-688-3137Fax: 614-247-6842
  • Molecular Biology and Cancer Genetics

Current Publications

  • Guttridge DCModeling human cancer cachexia in colon 26 tumor-bearing adult mice.J Cachexia Sarcopenia Muscle 3/26/2014
  • Croce CMMicrovesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7.Proc Natl Acad Sci U S A 111 4525-9 3/25/2014
  • Der-Torossian HCancer Cachexia Update in Head and Neck Cancer: Pathophysiology and Treatment.Head Neck 3/14/2014
  • Iwenofu OHExpression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma.Mod Pathol 1/24/2014
  • Der-Torossian HCancer cachexia update in head and neck cancer: Definitions and diagnostic features.Head Neck 1/10/2014
  • He WA, Berardi E, Cardillo VM, Acharyya S, Aulino P, Thomas-Ahner J, Wang J, Bloomston M, Muscarella P, Nau P, Shah N, Butchbach ME, Ladner K, Adamo S, Rudnicki MA, Keller C, Coletti D, Montanaro F, Guttridge DCNF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia.J Clin Invest in press 10/1/2013
  • Guttridge DCMechanisms of impaired differentiation in rhabdomyosarcoma.FEBS J 280(17) 4323-34 9/1/2013
  • Remels AH, Gosker HR, Bakker J, Guttridge DC, Schols AM, Langen RCRegulation of skeletal muscle oxidative phenotype by classical NF-κB signalling.Biochim Biophys Acta 1832(8) 1313-25 8/1/2013
  • Yaseen Balkhi M, Iwenofu OH, Bakkar N, Ladner KJ, Chandler DS, Houghton PJ, London CA, Kraybill W, Perrotti D, Croce CM, Keller C, Guttridge DCmiR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR.Sci Signal 6(286) ra63 7/30/2013
  • Rudnicki MARetraction: MyoD-dependent regulation of NF-κB activity couples cell-cycle withdrawal to myogenic differentiation.Skelet Muscle 3(1) 15 7/18/2013
  • Bekaii-Saab TSDisrupting cytokine signaling in pancreatic cancer: a phase I/II study of etanercept in combination with gemcitabine in patients with advanced disease.Pancreas 42(5) 813-8 7/1/2013
  • Guttridge DCReining in nuclear factor-kappaB in skeletal muscle disorders.Curr Opin Clin Nutr Metab Care 16(3) 251-7 5/1/2013
  • Hemminger JA, Ewart Toland A, Scharschmidt TJ, Mayerson JL, Kraybill WG, Guttridge DC, Iwenofu OHThe cancer-testis antigen NY-ESO-1 is highly expressed in myxoid and round cell subset of liposarcomas.Mod Pathol 26(2) 282-8 2/1/2013
  • Burkin DJReport on the Myomatrix Conference April 22-24, 2012, University of Nevada, Reno, Nevada, USA.Neuromuscul Disord 23(2) 188-91 2/1/2013
  • Guttridge DCMechanisms for maintaining muscle.Curr Opin Support Palliat Care 6(4) 451-6 12/1/2012
  • Fearon KC, Glass DJ, Guttridge DCCancer cachexia: mediators, signaling, and metabolic pathways.Cell Metab 16(2) 153-66 8/8/2012
  • Robbins PDNF-κB inhibition delays DNA damage-induced senescence and aging in mice.J Clin Invest 122(7) 2601-12 7/2/2012
  • Balkhi MY, Willette-Brown J, Zhu F, Chen Z, Liu S, Guttridge DC, Karin M, Hu YIKKα-mediated signaling circuitry regulates early B lymphopoiesis during hematopoiesis.Blood 119(23) 5467-77 6/7/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: