Denis Guttridge C PhD

Denis Guttridge C PhD
ProfessorCollege of
910 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-688-3137Fax: (614) 247-6842
  • Translational Therapeutics

Research Description

Dr. Guttridge's laboratory studies the NF-kB family of transcription factors and the role they play in cell growth and differentiation

Current Publications

  • Wang DJ, Ratnam NM, Byrd JC, Guttridge DCNF-κB Functions in Tumor Initiation by Suppressing the Surveillance of Both Innate and Adaptive Immune Cells.Cell Rep 9(1) 90-103 10/9/2014
  • Guttridge D, Couch M, Di Marco S, Gallouzi IE, Zitzmann ND, Baracos V, Rudnicki M, Tremblay M, Zimmers TAn invitation to the 2nd Cancer Cachexia Conference, Montréal, Canada.J Cachexia Sarcopenia Muscle 5 181 9/1/2014
  • Hemminger JA, Toland AE, Scharschmidt TJ, Mayerson JL, Guttridge DC, Iwenofu OHExpression of cancer-testis antigens MAGEA1, MAGEA3, ACRBP, PRAME, SSX2, and CTAG2 in myxoid and round cell liposarcoma.Mod Pathol 27 1238-45 9/1/2014
  • Garvey SM, Dugle JE, Kennedy AD, McDunn JE, Kline W, Guo L, Guttridge DC, Pereira SL, Edens NKMetabolomic profiling reveals severe skeletal muscle group-specific perturbations of metabolism in aged FBN rats.Biogerontology 15 217-32 6/1/2014
  • Talbert EE, Metzger GA, He WA, Guttridge DCModeling human cancer cachexia in colon 26 tumor-bearing adult mice.J Cachexia Sarcopenia Muscle in press 3/26/2014
  • He WA, Calore F, Londhe P, Canella A, Guttridge DC, Croce CMMicrovesicles containing miRNAs promote muscle cell death in cancer cachexia via TLR7.Proc Natl Acad Sci U S A 111 4525-9 3/25/2014
  • Couch ME, Dittus K, Toth MJ, Willis MS, Guttridge DC, George JR, Chang EY, Gourin CG, Der-Torossian HCancer Cachexia Update in Head and Neck Cancer: Pathophysiology and Treatment.Head Neck in press 3/14/2014
  • Frakes AE, Ferraiuolo L, Haidet-Phillips AM, Schmelzer L, Braun L, Miranda CJ, Ladner KJ, Bevan AK, Foust KD, Godbout JP, Popovich PG, Guttridge DC, Kaspar BKMicroglia induce motor neuron death via the classical NF-κB pathway in amyotrophic lateral sclerosis.Neuron 81 1009-23 3/5/2014
  • Couch ME, Dittus K, Toth MJ, Willis MS, Guttridge DC, George JR, Barnes CA, Gourin CG, Der-Torossian HCancer cachexia update in head and neck cancer: Definitions and diagnostic features.Head Neck in press 1/10/2014
  • Onesti JK, Guttridge DCInflammation Based Regulation of Cancer Cachexia.Biomed Res Int 2014 168407 1/1/2014
  • Wagers AJ, Keller C, Hettmer S, Li Z, Billin AN, Barr FG, Cornelison DD, Ehrlich AR, Guttridge DC, Hayes-Jordan A, Helman LJ, Houghton PJ, Khan J, Langenau DM, Linardic CM, Pal R, Partridge TA, Pavlath GK, Rota R, Schäfer BW, Shipley J, Stillman B, Wexler LHRhabdomyosarcoma: Current Challenges and Their Implications for Developing Therapies.Cold Spring Harb Perspect Med 4 1/1/2014
  • He WA, Berardi E, Cardillo VM, Acharyya S, Aulino P, Thomas-Ahner J, Wang J, Bloomston M, Muscarella P, Nau P, Shah N, Butchbach ME, Ladner K, Adamo S, Rudnicki MA, Keller C, Coletti D, Montanaro F, Guttridge DCNF-κB-mediated Pax7 dysregulation in the muscle microenvironment promotes cancer cachexia.J Clin Invest 123 4821-35 11/1/2013
  • Keller C, Guttridge DCMechanisms of impaired differentiation in rhabdomyosarcoma.FEBS J 280 4323-34 9/1/2013
  • Remels AH, Gosker HR, Bakker J, Guttridge DC, Schols AM, Langen RCRegulation of skeletal muscle oxidative phenotype by classical NF-κB signalling.Biochim Biophys Acta 1832 1313-25 8/1/2013
  • Balkhi MY, Iwenofu OH, Bakkar N, Ladner KJ, Chandler DS, Houghton PJ, London CA, Kraybill W, Perrotti D, Croce CM, Keller C, Guttridge DCmiR-29 acts as a decoy in sarcomas to protect the tumor suppressor A20 mRNA from degradation by HuR.Sci Signal 6 ra63 7/30/2013
  • Wu C, Fernandez SA, Criswell T, Chidiac TA, Guttridge D, Villalona-Calero M, Bekaii-Saab TSDisrupting cytokine signaling in pancreatic cancer: a phase I/II study of etanercept in combination with gemcitabine in patients with advanced disease.Pancreas 42 813-8 7/1/2013
  • Shintaku J, Guttridge DCReining in nuclear factor-kappaB in skeletal muscle disorders.Curr Opin Clin Nutr Metab Care 16 251-7 5/1/2013
  • Hemminger JA, Ewart Toland A, Scharschmidt TJ, Mayerson JL, Kraybill WG, Guttridge DC, Iwenofu OHThe cancer-testis antigen NY-ESO-1 is highly expressed in myxoid and round cell subset of liposarcomas.Mod Pathol 26 282-8 2/1/2013
  • Rutkowski A, Bönnemann C, Brown S, Thorsteinsdóttir S, Dominov J, Ruegg MA, Matter ML, Guttridge D, Crosbie-Watson RH, Kardon G, Nagaraju K, Girgenrath M, Burkin DJReport on the Myomatrix Conference April 22-24, 2012, University of Nevada, Reno, Nevada, USA.Neuromuscul Disord 23 188-91 2/1/2013
  • Parker MH, von Maltzahn J, Bakkar N, Al-Joubori B, Ishibashi J, Guttridge D, Rudnicki MARetraction: MyoD-dependent regulation of NF-κB activity couples cell-cycle withdrawal to myogenic differentiation.Skelet Muscle 3 15 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: