Patrick Nana-Sinkam MD


Patrick Nana-Sinkam MD
Assoc ProfessorCollege of Medicinenana-sinkam.1@osu.edu
201 Davis Heart & Lung Research Inst 473 W 12th Avenue Columbus Ohio 43210
Phone:614-293-4925Fax:
  • Translational Therapeutics

Research Description

Dr. Nana-Sinkam's lab is focused on integrating both genomic and proteomic platforms to discover new biomarkers that may be used in the diagnosis, treatment and surveillance of tobacco related lung diseases.

Current Publications

  • Nana-Sinkam S, Croce CMMicroRNA regulation of tumorigenesis, cancer progression and interpatient heterogeneity: towards clinical use.Genome Biol in press 8/31/2014
  • Brown D, Rahman M, Nana-Sinkam SPmicroRNAs in Respiratory Diseases : A Clinician's Overview.Ann Am Thorac Soc in press 8/29/2014
  • Rahman M, Lovat F, Romano G, Calore F, Acunzo M, Bell EH, Nana-Sinkam PmiR-15b/16-2 regulates factors that promote p53 phosphorylation and augments the DNA damage response following radiation in the lung.J Biol Chem in press 8/4/2014
  • Nana-Sinkam SP, Choi AMEpigenetics and the unfolded protein response in the lung: emerging role for microRNAs.Am J Respir Crit Care Med 189 239-40 2/1/2014
  • Lee LJ, Wu Y, Kwak KJ, Agarwal K, Marras A, Wang C, Mao Y, Huang X, Ma J, Yu B, Lee R, Vachani A, Marcucci G, Byrd JC, Muthusamy N, Otterson G, Huang K, Castro CE, Paulaitis M, Nana-Sinkam SPDetection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons.Anal Chem 85 11265-74 12/3/2013
  • Kotha SR, Piper MG, Patel RB, Sliman S, Malireddy S, Zhao L, Baran CP, Nana-Sinkam PS, Wewers MD, Romberger D, Marsh CB, Parinandi NLPhospholipase A(2) activation by poultry particulate matter is mediated through extracellular signal-regulated kinase in lung epithelial cells: regulation of interleukin-8 release.Cell Biochem Biophys 67 415-29 11/1/2013
  • Liu L, Luo Z, Sun HL, Cui R, Wei H, Kim T, Lee TJ, Jeon YJ, Nuovo GJ, Volinia S, He Q, Yu J, Nana-Sinkam P, Croce CM, Peng Y, Dai Y, Hitchcock C, Yang X, Kassis ESInsulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer.Proc Natl Acad Sci U S A 110 15043-8 9/10/2013
  • Powell CA, Halmos B, Nana-Sinkam SPUpdate in lung cancer and mesothelioma 2012.Am J Respir Crit Care Med 188 157-66 7/15/2013
  • Wu Y, Terp MC, Kwak KJ, Gallego-Perez D, Nana-Sinkam SP, Lee LJSurface-mediated nucleic acid delivery by lipoplexes prepared in microwell arrays.Small 9 2358-67 7/8/2013
  • Acunzo M, Romano G, Palmieri D, Laganá A, Garofalo M, Balatti V, Drusco A, Chiariello M, Nana-Sinkam P, Croce CMCross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2.Proc Natl Acad Sci U S A 110 8573-8 5/21/2013
  • Nana-Sinkam SP, Powell CAMolecular biology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.Chest 143 e30S-9S 5/1/2013
  • Dakhlallah D, Batte K, Wang Y, Cantemir-Stone CZ, Yan P, Nuovo G, Mikhail A, Hitchcock CL, Wright VP, Nana-Sinkam SP, Piper MG, Marsh CBEpigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis.Am J Respir Crit Care Med 187 397-405 2/15/2013
  • Nana-Sinkam SP, Croce CMClinical applications for microRNAs in cancer.Clin Pharmacol Ther 93 98-104 1/1/2013
  • Kang HW, Crawford M, Fabbri M, Nuovo G, Garofalo M, Nana-Sinkam SP, Friedman AA mathematical model for microRNA in lung cancer.PLoS One 8 e53663 1/1/2013
  • Wu Y, Crawford M, Mao Y, Lee RJ, Davis IC, Elton TS, Lee LJ, Nana-Sinkam SPTherapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer.Mol Ther Nucleic Acids 2 e84 1/1/2013
  • Romano G, Crawford M, Nana-Sinkam P, Croce CM, Garofalo M, Jeon YJ, Nuovo GJ, Middleton J, Secchiero P, Joshi P, Alder H, Nazaryan N, Di Leva GMiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer.PLoS One 8 e67581 1/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu