Patrick Nana-Sinkam MD

Patrick Nana-Sinkam MD
Assoc ProfessorCollege of
201 Davis Heart & Lung Research Inst 473 W 12th Avenue Columbus Ohio 43210
  • Translational Therapeutics

Research Description

Dr. Nana-Sinkam's lab is focused on integrating both genomic and proteomic platforms to discover new biomarkers that may be used in the diagnosis, treatment and surveillance of tobacco related lung diseases.

Current Publications

  • Nana-Sinkam SP, Choi AMEpigenetics and the unfolded protein response in the lung: emerging role for microRNAs.Am J Respir Crit Care Med 189 239-40 2/1/2014
  • Wu Y, Kwak KJ, Agarwal K, Marras A, Wang C, Mao Y, Huang X, Ma J, Yu B, Lee R, Vachani A, Marcucci G, Byrd JC, Muthusamy N, Otterson G, Huang K, Castro CE, Paulaitis M, Nana-Sinkam SP, Lee LJDetection of extracellular RNAs in cancer and viral infection via tethered cationic lipoplex nanoparticles containing molecular beacons.Anal Chem 85 11265-74 12/3/2013
  • Kotha SR, Piper MG, Patel RB, Sliman S, Malireddy S, Zhao L, Baran CP, Nana-Sinkam PS, Wewers MD, Romberger D, Marsh CB, Parinandi NLPhospholipase A(2) activation by poultry particulate matter is mediated through extracellular signal-regulated kinase in lung epithelial cells: regulation of interleukin-8 release.Cell Biochem Biophys 67 415-29 11/1/2013
  • Jeon YJ, Nuovo GJ, Volinia S, He Q, Yu J, Nana-Sinkam P, Croce CM, Peng Y, Dai Y, Hitchcock C, Yang X, Kassis ES, Liu L, Luo Z, Sun HL, Cui R, Wei H, Kim T, Lee TJInsulin growth factor signaling is regulated by microRNA-486, an underexpressed microRNA in lung cancer.Proc Natl Acad Sci U S A 110 15043-8 9/10/2013
  • Powell CA, Halmos B, Nana-Sinkam SPUpdate in lung cancer and mesothelioma 2012.Am J Respir Crit Care Med 188 157-66 7/15/2013
  • Wu Y, Terp MC, Kwak KJ, Gallego-Perez D, Nana-Sinkam SP, Lee LJSurface-mediated nucleic acid delivery by lipoplexes prepared in microwell arrays.Small 9 2358-67 7/8/2013
  • Palmieri D, Laganá A, Garofalo M, Balatti V, Drusco A, Chiariello M, Nana-Sinkam P, Croce CM, Acunzo M, Romano GCross-talk between MET and EGFR in non-small cell lung cancer involves miR-27a and Sprouty2.Proc Natl Acad Sci U S A 110 8573-8 5/21/2013
  • Nana-Sinkam SP, Powell CAMolecular biology of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines.Chest 143 e30S-9S 5/1/2013
  • Dakhlallah D, Batte K, Wang Y, Cantemir-Stone CZ, Yan P, Nuovo G, Mikhail A, Hitchcock CL, Wright VP, Nana-Sinkam SP, Piper MG, Marsh CBEpigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis.Am J Respir Crit Care Med 187 397-405 2/15/2013
  • Nana-Sinkam SP, Croce CMClinical applications for microRNAs in cancer.Clin Pharmacol Ther 93 98-104 1/1/2013
  • Kang HW, Crawford M, Fabbri M, Nuovo G, Garofalo M, Nana-Sinkam SP, Friedman AA mathematical model for microRNA in lung cancer.PLoS One 8 e53663 1/1/2013
  • Wu Y, Crawford M, Mao Y, Lee RJ, Davis IC, Elton TS, Lee LJ, Nana-Sinkam SPTherapeutic Delivery of MicroRNA-29b by Cationic Lipoplexes for Lung Cancer.Mol Ther Nucleic Acids 2 e84 1/1/2013
  • Alder H, Nazaryan N, Di Leva G, Romano G, Crawford M, Garofalo M, Jeon YJ, Nuovo GJ, Middleton J, Secchiero P, Joshi P, Nana-Sinkam P, Croce CMMiR-34a/c-Dependent PDGFR-α/β Downregulation Inhibits Tumorigenesis and Enhances TRAIL-Induced Apoptosis in Lung Cancer.PLoS One 8 e67581 1/1/2013
  • Wu Y , Duan W, Otterson GA, Lee L, Nana-Sinkam PResearch Highlight: miRNA and platinum-based chemotherapy response in non-small-cell lung cancerPersonalized Medicine 9 329-32 11/1/2012
  • Huang Y, Crawford M, Higuita-Castro N, Nana-Sinkam P, Ghadiali SNmiR-146a regulates mechanotransduction and pressure-induced inflammation in small airway epithelium.FASEB J 26 3351-64 8/1/2012
  • Fabbri M, Paone A, Calore F, Galli R, Gaudio E, Santhanam R, Lovat F, Fadda P, Mao C, Nuovo GJ, Zanesi N, Crawford M, Ozer GH, Wernicke D, Alder H, Caligiuri MA, Nana-Sinkam P, Perrotti D, Croce CMMicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response.Proc Natl Acad Sci U S A 109 E2110-6 7/31/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: