Joanna Groden L PhD


Joanna Groden L PhD
Vice DeanCollege of Medicinegroden.2@osu.edu
986 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
Phone:614-688-4301Fax: (614) 292-4080
  • Molecular Biology and Cancer Genetics

General Research Interest

cancer genetics

Research Description

The Groden Laboratory has three primary areas of interest: the study of Bloom's syndrome, an inherited disorder that decreases chromosome stability and increases susceptibility to all types of cancer, the study of inherited disorders that increase susceptibility to colorectal cancer, especially familial adenomatous polyposis coli, and using the mouse as a model organism to learn more about how human cancers form and how we might diagnose and treat them. One aim of our laboratory is to understand the relationship between chromosome stability and neoplasia through study of the BLM helicase. BLM carries out very basic and important tasks within the cell, such as telomere elongation, resolution of stalled replication forks and responses to DNA damage. A second area of focus is to understand the genes that are altered in the development of colorectal cancer. Through study of the APC tumor suppressor and its functions in regulating the Wnt signaling pathway, we are investigating how downstream gene expression is regulated and how APC contributes to cell cycle regulation and apoptosis. Lastly, through the ability to manipulate the mouse genome, new mouse models of cancer are being developed and characterized in the laboratory. These model systems provide access to tumor material and are being used to test new ideas about the genes and their variants that affect susceptibility to cancer, as well as important environmental agents that affect tumor development.

Current Publications

  • Cascione L, Sumani KM, Valeri N, Braconi C, Gasparini P, Murgia C, Lampis A, Paulus-Hock V, Hart JR, Ueno L, Grivennikov SI, Lovat F, Paone A, Veronese A, Fabbri M, Carasi S, Alder H, Lanza G, Gafa' R, Moyer MP, Ridgway RA, Cordero J, Nuovo GJ, Frankel WL, Rugge M, Fassan M, Groden J, Vogt PK, Karin M, Sansom OJ, Croce CMMicroRNA-135b promotes cancer progression by acting as a downstream effector of oncogenic pathways in colon cancer.Cancer Cell 25 469-83 4/14/2014
  • Groden J, Gocha AR, Acharya SWRN Loss Induces Switching of Telomerase-Independent Mechanisms of Telomere Elongation.PLoS One 9 e93991 1/1/2014
  • Acharya S, Kaul Z, Gocha AS, Martinez AR, Harris J, Parvin JD, Groden JAssociation of BLM and BRCA1 during Telomere Maintenance in ALT Cells.PLoS One 9 e103819 1/1/2014
  • Amunugama R, Groden J, Fishel RThe HsRAD51B-HsRAD51C stabilizes the HsRAD51 nucleoprotein filament.DNA Repair (Amst) 12 723-32 9/1/2013
  • Grierson PM, Acharya S, Groden JCollaborating functions of BLM and DNA topoisomerase I in regulating human rDNA transcription.Mutat Res 743-744 89-96 3/1/2013
  • Gocha AR, Harris J, Groden JAlternative mechanisms of telomere lengthening: permissive mutations, DNA repair proteins and tumorigenic progression.Mutat Res 743-744 142-50 3/1/2013
  • Gocha AR, Nuovo G, Iwenofu OH, Groden JHuman sarcomas are mosaic for telomerase-dependent and telomerase-independent telomere maintenance mechanisms: implications for telomere-based therapies.Am J Pathol 182 41-8 1/1/2013
  • Groden J, Burt RGenotypes and phenotypes: animal models of familial adenomatous polyposis coli.Gastroenterology 143 1133-5 11/1/2012

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu