Yuri Pekarsky PhD

Yuri Pekarsky PhD
Res Asst ProfessorCollege of Medicinepekarsky.1@osu.edu
1090 Biomedical Research Tower 460 W 12th Avenue Columbus Ohio 43210
  • Molecular Biology and Cancer Genetics

General Research Interest

Molecular mechanisms of the pathohenesis of leukemias and lymphomas

Research Description

Mature T-cell leukemia commonly shows chromosomal rearrangements at 14q32.1 including translocations t(14;14)(q11;q32), t(7;14)(q35;q32) and inversions inv(14)(q11;q32). The investigation of the locus in question at 14q32.1 resulted in the identification of two related genes named TCL1 and TCL1b. Both genes are activated in T-PLL/T-CLL by the chromosomal aberrations mentioned above. Recently we discovered that biochemically, TCL1 works as a co-factor of the Akt kinase, a key regulator of antiapoptotic and proliferative signals. Tcl1 interacts physically with Akt, increases its kinase activity and facilitates its transport to the nucleus. The pathogenesis of T-PLL/T-CLL may also involve Nur77, a T-cell transcription factor required for T-cell receptor (TCR) mediated apoptosis. In our recent publication we demonstrate that Akt phosphorylates Nur77, thereby blocking its DNA-binding ability and rendering the transcription factor inactive. Currently we concentrate on studying of downstream events of this pathway as well as on the identification new pathways involving Tcl1 and Akt.

Current Publications

  • Acunzo M, Romano G, Wernicke D, Balatti V, Rassenti LZ, dell'Aquila M, Kipps TJ, Pekarsky Y, Croce CMTranslocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene.Blood 124 259-62 7/10/2014
  • Pekarsky Y, Croce CMRole of miR-15/16 in CLL.Cell Death Differ in press 6/27/2014
  • Croce CM, Drusco A, Nuovo GJ, Zanesi N, Di Leva G, Pichiorri F, Volinia S, Fernandez C, Antenucci A, Costinean S, Bottoni A, Rosito IA, Liu CG, Burch A, Acunzo M, Pekarsky Y, Alder H, Ciardi AMicroRNA Profiles Discriminate among Colon Cancer Metastasis.PLoS One 9 e96670 1/1/2014
  • Fassan M, Volinia S, Lovat F, Balatti V, Pekarsky Y, Croce CM, Sandhu SKB-cell malignancies in microRNA Eμ-miR-17~92 transgenic mice.Proc Natl Acad Sci U S A 110 18208-13 11/5/2013
  • Zanesi N, Balatti V, Riordan J, Burch A, Rizzotto L, Palamarchuk A, Cascione L, Lagana A, Dupuy AJ, Croce CM, Pekarsky YA Sleeping Beauty screen reveals NF-kB activation in CLL mouse model.Blood 121 4355-8 5/23/2013
  • Rassenti LZ, Bottoni A, Palamarchuk A, Cascione L, Alder H, Keating MJ, Kipps TJ, Pekarsky Y, Croce CM, Balatti V, Lerner S, Rizzotto LTrisomy 12 CLLs progress through NOTCH1 mutations.Leukemia 27 740-3 3/1/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 460 W. 10th Avenue, Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu