General Research InterestThe role of the Mps1 protein kinase in centrosome assembly and genomic instability
Research Description Centrosomes are microtubule-organizing structures that coordinate mitotic spindle assembly and chromosome segregation. Centrosome aberrations are found in a variety of tumors, and are associated with tumorigenesis in breast cancer, prostate cancer, and leukemia. Centrosome duplication is controlled by the Mps1 protein kinase, and misregulation of Mps1 correlates with both centrosome aberrations and tumorigenesis. I have identified an Mps1 mutation that causes centrosome aberrations. My research program will investigate the function of Mps1 in centrosome duplication, the contribution of Mps1 to centrosome aberrations in human tumors, and the contribution of Mps1 dysfunction to centrosome defects and tumorigenesis.
Transinstitutional WorkDr. Fisk has been a co-organizer of the OSU CCC MBCG program bi-annual retreat in 2005 and 2007, has served as a member of the MCDB/OSBP seminar committee since 2006, participates in grant review for the Molecular Genetics Internal Grant Review Committee, is a member of the OSU CCC Tumor Microenvironment Search Committee, and is a member of the Ohio State University Radiation Safety Committee. Dr. Fisk has also reviewed grants for the Texas Advanced Research Program and is a member of the American Cancer Society Cell Cycle and Growth Control Study Section. Dr. Fisk interacts with Drs. Leone, Ostrowski, and Perrotti of the OSU CCC who have provided Dr. Fisk with advice, reagents, and mentorship on animal experimentation and tumorigenesis. Dr. Fisk also collaborates with Dr. Ford of the University of Colorado Health Sciences Center in Denver, Colorado, on the role of Mps1 in Cyclin A-dependent aneuploidy.