Zucai Suo PhD


Zucai Suo PhD
ProfessorArts and Sciencessuo.3@osu.edu
880 Bioscience Building 484 W 12th Avenue Columbus Ohio 43210
Phone:614-688-3706Fax: 614-292-6773
  • Molecular Biology and Cancer Genetics

General Research Interest

Employing advanced enzymology to investigate DNA polymerases, kinases, and proteases.

Research Description

Three major research projects in the Suo laboratory: i) using pre-steady state kinetic techniques (rapid chemical quench flow and stopped flow) and single molecule methods to elucidate kinetic mechanisms for DNA polymerases, kinases, and proteases; ii) develop small molecules to inhibit hepatitis C infections; and iii) investigate the efficacy and toxicity of antiviral and anticancer nucleoside analogs.

Transinstitutional Work

We have collaborated with the following groups in the past several years: Dr. Hong Ling, an X-ray Crystallographer at University of Western Ontario, Canada; Dr. John-Stephen Taylor, a chemist at Washington University at St. Louis; and Dr. Ashis Basu, a chemist at University of Connecticut.  

Current Publications

  • Suo ZKinetic mechanism of DNA polymerization catalyzed by human DNA polymerase ε.Biochemistry 52(40) 10/8/2013

The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC – James) 300 W. 10th Ave. Columbus, OH 43210 Phone: 1-800-293-5066 | Email: jamesline@osumc.edu