The Molecular Biology & Cancer Genetics (MBCG) research program is one of
OSUCCC–James' six highly interactive cancer Research Programs. The programs comprise more than 200 leading scientists from 13 different colleges within Ohio State and affiliated academic institutions. The MBCG membership includes 49 cancer-focused scientists.
Devoted to scientific excellence and to multidisciplinary, translational research, MBCG focuses on understanding the control of gene expression as it relates to cellular proliferation, DNA replication, differentiation, developmental regulation and the molecular basis of cancer. This focus promotes clinical application of gene identification that leads to improved screening, diagnosis, prognosis and treatment.
Our primary goal is to increase understanding of the association between genes and cancer and to exploit this association to reduce cancer-related deaths. To achieve this goal, our objectives are to:
- Identify human genes that, either through direct mutations or epigenetic mechanisms, lead to an increased predisposition to cancer
- Determine molecular mechanisms underlying gene expression and function that contribute to normal development and multi-stage cancer progression
- Promote clinical applications of gene identification and gene-function understanding for better diagnosis, prognosis, surveillance, prevention and cancer treatment.
Michael C. Ostrowski, PhD
Albert de la Chapelle, MD, PhD