Amanda Harper and Elizabeth McMichael were chosen to give talks at the Biomedical Sciences Graduate Program Retreat. Amanda Harper gave her talk on, “Monocyte Expression of MICA Enhances the Natural Killer Cell Response to Antibody- Coated Tumor Targets.” Elizabeth McMichael gave her talk, entitled, “IL-21 enhances natural killer cell activity against cetuximab-coated pancreatic tumor cells.”
Dr. Joseph Markowtiz, MD/PhD attended the AACR Immunology meeting in Florida and presented his poster entitled, “Nitroaspirins abrogate myeloid derived suppressor cell inhibition of dendritic cell antigen presentation to CD4+ T cells in pancreatic adenocarcinoma.”
Carson lab first year IBGP graduate student Megan Duggan was awarded a Career Development Grant from the Council of Graduate Students.
The entire Carson Lab participated in the OSU CCC James’ Hope for the Holiday program, and was able to help make Christmas gifts possible for a family of four.
Amanda Harper attended the SITC conference and gave an oral presentation of her work, entitled, “Monocyte Expression of MICA Enhances the Natural Killer Cell Response to Antibody- Coated Tumor Targets.”
Gonzalo Olaverria-Salavaggione and Tiffany Noel joined the Carson lab as undergraduate volunteers.
Amanda Harper, an MD/PhD candidate in the Carson Lab, had a talk at the OSU Comprehensive Cancer Center Translational Therapeutics retreat entitled, “A Factor VII-IgG Fc Fusion Protein and Interleukin-15 to Promote Natural Killer Cell Activity Against Metastatic Melanoma.”
Elizabeth McMichael, a PhD candidate in the Carson lab, had a poster at the OSU Comprehensive Cancer Center Translational Therapeutics retreat entitled, “Enhancement of cetuximab-induced antibody-dependent cellular cytotoxicity with lenalidomide in advanced solid tumors: A Phase I trial.”
Dr. Prashant Trikha, a senior researcher in the Carson lab, had a poster at the OSU Comprehensive Cancer Center Translational Therapeutics retreat entitled, “Modulation of Myeloid-Derived Suppressor Cell Function with Ibrutinib, a Bruton’s Tyrosine Kinase Inhibitor.”
Dr. Nicholas Latchana, a surgical resident in the Carson lab, had a poster at the OSU Comprehensive Cancer Center Translational Therapeutics retreat entitled, “Classification of Indeterminate Melanocytic Lesions by MicroRNA Profiling.”
IBGP first year graduate student Leslee Sprague began rotating in the lab. Les is working on a project looking at the genes involved in Dr. Carson’s clinical trial OSU-07033, “A Pilot Study of IFN-alpha-2b Dose Reduction with Dose Optimization” in patients with melanoma.
Amanda Harper, an MD/PhD candidate in the Carson Lab, presented her work entitled, “Characterization of IL-2 Receptor Alpha Expression on Dual Stimulated Natural Killer Cells” for the Medical Scientist Student Organization retreat.
Andrew Stiff, an MD/PhD candidate in the Carson Lab, presented his talk, “Using cancer epigenetics to enhance the therapeutic potential of reovirus in multiple myeloma” for the Pelotonia committee.
Dr. Nicholas Latchana, a surgical resident in the Carson lab, presented his talk entitled, “Classification of Indeterminate Melanocytic Lesions by MicroRNA Profiling” at the Perspectives in Melanoma XVIII conference in Dublin, Ireland.
The Carson lab published a paper entitled, “Adjuvant Vaccine Immunotherapy of Resected, Clinically Node-negative Melanoma: Long-Term Outcome and Impact of HLA Class I Antigen Expression on Overall Survival” in Cancer Immunology Research
Andrew Stiff officially joined the Carson Lab as a graduate research fellow in order to complete the PhD portion of his dual MD/PhD degree.
Katia Fernandez-Soto presented her presentation and poster entitled, “IL-21 Enhances the Natural Killer Cell Response to Cetuximab-Coated Pancreatic Tumor Cells” at the end-of-the-summer SUCCESS student research forum.
Katia, Smita, and Akaansha completed their summer research projects and returned to their home institutions. Good luck!
Andrew Stiff, an MD/PhD student, rotated in the Carson Lab. He worked on a project examining the effects of NRAS in melanoma.
Katia Fernandez-Soto, an undergraduate student from the University of Notre Dame, joined the Carson lab for the summer to work on a project involving the Folate Fc receptor.
Smita Madhukar, an undergraduate student from IISER-Pune in India, joined the Carson Lab in order to complete a summer research project in collaboration with Pelotonia and her home institution.
Akaansha Ganju, an M2 from NEOMED, joined the Carson lab in order to complete a summer research project.
Megan Duggan, former Carson Lab employee, matriculated to graduate school in the Biomedical Sciences Graduate Program and officially joined the lab as a graduate research fellow.
Dr. Nicholas Latchana, a surgical resident in the Carson lab, presented on his project, “miR-21 Enhances Melanoma Invasiveness via Inhibition of Tissue Inhibitor of Metalloproteinases 3 Expression: In vivo Effects of miR 21 Inhibitor” at the OSU Department of Surgery Research Day.
Dr. Nicholas Latchana, a surgical resident in the Carson lab, presented his poster entitled, “Classification of Indeterminate Melanocytic Lesions by MicroRNA Profiling” at the ACS Ohio Annual Chapter Meeting in Cleveland, OH.
Undergraduate Jyh-haur Vincent Hsu has been awarded a summer fellowship! He received the Undergraduate Education Research Fellowship.
Undergraduate Gregory Kemper has been awarded a summer fellowship! He received the Undergraduate Education Research Fellowship.
The Carson Lab was well represented at the Wexner Medical Center’s annual Research Day, with general surgery resident Dr. Nicholas Latchana presenting his poster, “Classification of Indeterminate Melanocytic Lesions by Micro RNA Profiling.” Postdoctoral researcher Dr. Joseph Markowitz presenting his poster, “Immune Suppressive Myeloid Cells are Induced During Disease Progression in Patients with Advanced Pancreatic Adenocarcinoma.” MD/PhD trainee Amanda Harper presenting her poster, “Monocyte Expression of MICA Enhances the Natural Killer Cell Response to Antibody-Coated Tumor Targets.” Finally, PhD candidate Elizabeth McMichael presented her poster, “Enhancement of Cetuximab Induced Antibody Dependent Cellular Cytotoxicity with Lenalidomide in Advanced Solid Tumors: A Phase I Trial.”
Prashant Trikha, PhD attended the 2014 American Association for Cancer Research annual meeting in San Diego. Dr. Trikha’s abstract for this meeting was, “MDSC-generated nitric oxide leads to an impairment of NK cell functions in metastatic melanoma patients.”
Joseph Markowitz, MD/PhD also attended attended the 2014 American Association for Cancer Research annual meeting in San Diego.
Undergraduate Gregory Kemper attended the National Conference on Undergraduate Research at the University of Kentucky.
Dr. Nicholas Latchana, a surgical resident in the Carson lab, presented his poster entitled, “Classification of Indeterminate Melanocytic Lesions by MicroRNA Profiling” at the OSUWMC 12th Annual Trainee Research Day.
Amanda Harper (MD/PhD- in-training) won first place at the annual MSTP Winter Retreat for her talk entitled, “Utilizing a Factor VII-IgG1 Fc Fusion Protein and Interleukin-15 to Promote Natural Killer Cell Activity in the Treatment of Cancer.”
Undergraduate student researcher Gregory Kemper won second place in a poster presentation at the Natural and Mathematical Sciences Research Forum for his poster entitled, “The Combination of MLN2238 with Inferferon-α Results in Synergistic Cell Death in Melanoma.”
Undergraduate student Jyh-haur Vincent Hsu presented a poster at the Denman Forum entitled, “Targeting Myeloid Derived Suppressor Cells in the Tumor Microenvironment.”
Undergraduate Gregory Kemper presented his posted, “The Combination of MLN2238 with Inferferon-α Results in Synergistic Cell Death in Melanoma” at the Denman Forum.
Carson Lab undergraduate Kallan Opheim has been awarded the Mayer’s Summer Research Scholarship for the summer of 2014!
The Carson Lab would like to welcome new undergraduate volunteer, Sarvani Uppati.
Joseph Markowitz, MD attended the 2014 Translational Research Cancer Centers Consortium in Seven Springs, Pennsylvania. Joseph had an invited talk entitled, “Inhibition of Myeloid-Derived Suppressor Cells in Pancreas Cancer.”
Dr. Nicholas Latchana, a surgical resident in the Carson lab, presented on his project, "Classification of Indeterminate Melanocytic Lesions by MicroRNA Profiling" at the Academic Surgical Conress in San Diego, CA.
Dr. Carson and Dr. Glaser’s clinical trial entitled, “A pilot study of beta-blockers in patients with advanced cancer” was opened by the Clinical Trials Office. This study is collaboration with Dr.Binkley, Dr. Kendra, Dr. Lemeshow, and Dr. Thomas Olencki.
The Carson Lab celebrated another year’s end with a white elephant gift exchange and an ugly sweater party at Buca di Beppo. Dr. Carson was the proud recipient of an oil painting portrait of himself, crafted by a Research Associate in the lab.
On November 20th, Amanda Harper passed her candidacy exam for graduate school. Go Amanda!
A manuscript from the Carson Lab entitled, “A Phase I trial of Bortezomib and Interferon Alpha-2B in Metastatic Melanoma” was accepted for publication by the Journal of Immunotherapy
IBGP first year graduate student Christina Knippler rotated in the Carson Lab. Christina worked with Elizabeth McMichael on projects involving the folate receptor, including in vitro and in vivo studies.
An implementation meeting for the new clinical trial “A pilot study of beta-blockers in patients with advanced cancer” was held this month.
Megan Duggan, who previously worked in Dr. Glaser’s lab, was hired by the Carson Lab! Megan will be managing the clinical trial “A pilot study of beta-blockers in patients with advanced cancer” for the Carson Lab.
The Carson lab welcomes new undergraduate volunteer Kallan Opheim.
Dr. Carson and Dr. Glaser’s clinical trial entitled, “A pilot study of beta-blockers in patients with advanced cancer” was approved by the Institutional Review Board. This study is a collaboration with Dr.Binkley, Dr. Kendra, Dr. Lemeshow, and Dr. Thomas Olencki.
The Carson Lab welcomes Megan Duggan, who will be working on a vaccine study and doing basic science research. Megan will manage the Beta-Blockers clinical trial on the lab side.
MD/PhD first year medical student Anisley Valenciaga rotated in the Carson lab. During her time in the lab, she worked on optimizing the annexin/PI assay for Caron Lab on cells treated with novel pharmaceuticals.
The Carson Lab would like to wish “good luck” to Bonnie Paul, who is leaving for a position as a clinical research assistant in Cardiovascular Medicine. Bonnie worked in the Carson lab for 3 years as a Research Assistant, helping with our clinical research on immune suppressor cells.
The Carson Lab welcomes Dr. Nicholas Latchana, the newest surgical resident to take time out for research. Nick will be continuing Sara’s work on miRs in melanoma.
Dr. Martin del Campo’s work with University of Mississippi Medical Center entitled “Metastatic Melanoma: Lactate Dehydrogenase Levels and CT Imaging Findings of Tumor Devascularization Allow Accurate Prediction of Survival in Patients Treated with Bevacizumab” was published in Radiology. Congratulations, Sara!
Dr. Martin del Campo has finished her stint in the Carson Lab and is returning to work as a third year surgical resident. During her time in the Carson Lab Sara worked on projects involving miRs in melanoma, and a clinical trial involving dose optimization of Cetuximab in head and neck cancer patients. Best wishes, Sara!
The Carson Lab would like to welcome Elizabeth McMichael, a graduate student who will be earning her PhD with us!
Good luck and best wishes to Dr. Cristina Jaime-Ramirez as she departs the Carson Lab to go on to new opportunities as a postdoctoral fellow with Dr. Kaur in the Department of Neurological Surgery! We will miss you!
January – March 2013
IBGP student Elizabeth McMichael rotated through the Carson lab this winter. During her rotation Liz completed work on the clinical trial “Enhancement of Cetuximab-Induced Antibody-Dependent Cellular Cytotoxicity (ADCC) with Lenalidomide in Advanced Solid Tumors: A Phase I Study” and presented the unified data to the lab.
Carson Lab undergraduate researcher Gregory Kemper received an honorable mention at the Denman Undergraduate Research Forum for his poster presentation.
Gregory Kemper was awarded the prestigious DAAD RISE (Deutcher Akadmedischer Austausch Dienst [German Academic Exhange Service] Research Interships in Engineering) Internship. Greg will be conducting research in Germany for the summer of 2013 !!
Cristina Jaime-Ramirez successfully defended her thesis, entitled “The NK Cell-mediated Anti-tumor Effects of a Folate-conjugated Immunoglobulin are Enhanced by Cytokines”. Congratulations Dr. Jaime-Ramirez!
Dr. Joseph Markowitz was awarded the highly prestigious Postdoctoral Pelotonia Fellowship Program. This program “provides two-year research fellowships for up to 12 of the brightest and most promising postdoctoral candidates who want to help cure cancer”.
Accrual to Dr. Carson's investigator-initiated trial of IL-12 and cetuximab in patients with head and neck cancer is continuing at a very successful rate.